Author(s): S.S. Chitlange, G. R. Pawbake, S.V.Pandkar, S.B.Wankhede

Email(s): sohanchitlange@rediffmail.com

DOI: Not Available

Address: S.S. Chitlange*, G. R. Pawbake, S.V.Pandkar, S.B.Wankhede
Padm. Dr.D.Y. Patil Institute of Pharmaceutical sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-411018, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2011


ABSTRACT:
Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Diacerein (DIA) is a poorly water- soluble anti-inflammatory analgesic and antipyretic drug, developed specially for the treatment of osteoarthritis. Due to the poor solubility of diacerein in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. In the present work, an attempt was made to improve the solubility and dissolution rate of a poorly water soluble drug, Diacerein by solid dispersion method using PEG-4000, PEG-6000 and PXM-407 as carriers. Solid dispersions of diacerein were prepared by solvent evaporation method and melt method separately with varying drug: carrier ratios viz.1:1, 1:2 and 1:3. The formulations were characterized for solubility parameters, percentage drug content, drug release studies and drug-polymer interactions by using saturation solubility studies, assay, invitro dissolution study, DSC, FTIR. All the formulations showed marked improvement in the solubility behavior and improved drug release. The drug content was found to be high and uniformly distributed in the all formulation. No chemical interaction was found between drug and carriers. Solid dispersions prepared by melt method shows faster dissolution of drug than solvent evaporation method. Formulation prepared by melt method containing drug: polymer ratio of 1:3 with PXM-407 showed the best release 97.44% in 70 min as compared to the pure drug i.e. 41.52 % in 120 min. It was concluded that PXM-407 as a carrier can be well utilized to improve the solubility and dissolution rate of poorly soluble drugs.


Cite this article:
S.S. Chitlange, G. R. Pawbake, S.V.Pandkar, S.B.Wankhede. Formulation and Evaluation of Diacerein Solid Dispersion for Solubility and Dissolution Rate Enhancement. Research J. Pharm. and Tech. 4(6): June 2011; Page 932-937.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Author(s): Sarumathy S., CH Haripriya, Muddala Vara Prasanna Rao, Gayathri K., CH Bala Sudhakar, Divya M., Shanmugasundaram P.

DOI: 10.5958/0974-360X.2015.00272.3         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags