R. Sivakumar, V. Ganesan, Markand Viyas, N.N. Rajendran, M. Kommala
R. Sivakumar1*, V. Ganesan1, Markand Viyas2, N.N. Rajendran2 and M. Kommala3
1The Erode College of Pharmacy, Erode – 638112 (TN)
2Swamy Vivekanandha College of Pharmacy, Tiruchengode - 637 205, India.
3Mohamed Sathak A.J. College of Pharmacy, Chennai-600 119
Volume - 4,
Issue - 6,
Year - 2011
The purpose of the work was to formulate and evaluate mucoadhesive microspheres containing metronidazole for the potential delivery of the drug to the colon. Microspheres were prepared by emulsion solvent evaporation method and filled into capsules for polymeric coating. These preparations were characterized for micromeritics study, morphology, percentage drug content, encapsulation efficiency, Percent mucoadhesion and in vitro drug release study. All the microspheres were spherical in shape smooth surface with a mean diameter 58.9 µm – 205.1 µm. The release mechanism were anomalous (non-fickian) diffusion mechanism. The prolonged colonic residence time and enhanced metronidazole stability resulting from the mucoadhesion microspheres of metronidazole might make contribution of complete eradication of amoebiasis.
Cite this article:
R. Sivakumar, V. Ganesan, Markand Viyas, N.N. Rajendran, M. Kommala. Metronidazole Encapsulation within Chitosan Coated Eudragit RL Microsphers for Site Specific Delivery. Research J. Pharm. and Tech. 4(6): June 2011; Page 993-996.