Author(s): Sushama D. Patil, Leena Patil, Vilasrao J. Kadam

Email(s): sushama1688@yahoo.in

DOI: Not Available

Address: Sushama D. Patil*, Leena Patil and Vilasrao J. Kadam
Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector 8 , C.B.D, Navi Mumbai 400614, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2011


ABSTRACT:
Oxidative damage is implicated in the pathogenesis of various liver injuries. The study was aimed to investigate the antioxidant activity of fruit of Luffa aegyptiaca Mill. on carbon tetrachloride (CCl4) induced oxidative stress in female wistar rats. CCl4 injection induced oxidative stress by a significant rise in serum marker enzymes and thiobarbituric acid reactive substances (TBARS) along with the reduction of antioxidant enzymes. In serum, the activities of enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) were evaluated. Pre-treatment of rats with different doses of plant extract (250 and 500 mg/kg) significantly lowered ALT, AST and TBARS levels against CCl4 treated rats. Hepatic enzymes like catalase and reduced glutathione were significantly increased by treatment with plant extract, against CCl4 treated rats. Histopathological examinations showed extensive liver injuries, characterized by extensive hepatocellular degeneration/ necrosis, inflammatory cell infiltration, congestion, and sinusoidal dilatation. Oral administration of the fruit extract at a dose of 500mg/kg body weight significantly reduced the toxic effects of CCl4. The activity of fruit extract at the dose of 500 mg/kg was comparable to the standard drug, silymarin. Based on these results, it was observed that Luffa aegyptiaca Mill. fruit extract protects liver from oxidative stress induced by CCl4 and thus helps in evaluation of traditional claim on this plant.


Cite this article:
Sushama D. Patil, Leena Patil, Vilasrao J. Kadam. Protective Effect of Ethanolic Extract of Fruit of Luffa aegyptiaca Mill. on Carbon Tetrachloride Induced Hepatotoxicity in Rats. Research J. Pharm. and Tech. 4(6): June 2011; Page 938-941.

Cite(Electronic):
Sushama D. Patil, Leena Patil, Vilasrao J. Kadam. Protective Effect of Ethanolic Extract of Fruit of Luffa aegyptiaca Mill. on Carbon Tetrachloride Induced Hepatotoxicity in Rats. Research J. Pharm. and Tech. 4(6): June 2011; Page 938-941.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2011-4-6-10


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Vandana Devi Sahu, Mukta Agrawal, Mukesh Sharma, Sandhya Chandrakar, Sujata Gupta, Garima Sharma, Kalyani Dewangan, Harsha Solanki, Manisha Majumdar, D. K. Tripathi, Amit Alexander, Ajazuddin

DOI: 10.5958/0974-360X.2016.00145.1         Access: Open Access Read More

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Author(s): A. Rajendra Kumar, N. J. Muthukumar, A. Faridha

DOI: 10.5958/0974-360X.2019.00081.7         Access: Open Access Read More

Author(s): Harsha Vardhani Kondepati, Girish Pai Kulyadi, Vamshi Krishna Tippavajhala

DOI: 10.5958/0974-360X.2018.00069.0         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags