Author(s): Indrayani D. Raut, Rahul S. Adnaik, Akshada N. Kakade, Sandip A. Bandgar, Dhanyakumar D. Chougule, Rohit. R. Shah

Email(s): indrayaniraut7363@rediffmail.com

DOI: Not Available

Address: Indrayani D. Raut1*, Rahul S. Adnaik1, Akshada N. Kakade1, Sandip A. Bandgar2, Dhanyakumar D. Chougule3 and Rohit. R. Shah3
1 Rajarambapu College of Pharmacy, Kasegaon.
2Ashokrao Mane College of Pharmacy, Peth-vadgaon.
3Appasaheb Birnale College of Pharmacy, Sangli.
*Corresponding Author

Published In:   Volume - 4,      Issue - 5,     Year - 2011


ABSTRACT:
Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist with antiemetic properties. Various methods for analysis of same are available but are time consuming and expensive. Various simultaneous method of Domperidone with another drug is available. Here we have developed new, precise, simple spectrophotometric method for estimation of Domperidone from bulk. Medium prepared were selected 0.1 N HCl having pH 1.2. It showed absorption maxima at 284nm.This method were validated according to ICH guidelines. The drug obeyed Beers law and showed good correlation. The linearity was observed between 0–20 mcg/mL. There was no significant difference in the intraday and interday analysis of Domperidone determined. The results of analysis were validated with respect to recovery, linearity; Limit of detection and limit of quantitation were found to be satisfactory.


Cite this article:
Indrayani D. Raut, Rahul S. Adnaik, Akshada N. Kakade, Sandip A. Bandgar, Dhanyakumar D. Chougule, Rohit. R. Shah. Validated Spectrophotometric Method for Estimation of Domperidone in Bulk and Pharmaceutical Formulation. Research J. Pharm. and Tech. 4(5): May 2011; Page 790-792.


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3.       British Pharmacopeia, Vol. I, Introduction, General notices, Monographs, Medical and Pharmaceutical substances, A-I, London, 2008:752-753.

4.       Ei-Gindy A, Emora S, Mostafa A. Method development of Domperidone by colorimetric. Farmaco. 2004; 59: 713-722.

5.       Sivakumar T, Manavalon K, Volliappan K. Development and validation of Reversed phase HPLC method for simultaneous determination of Domperidone and Pantoprazole in pharmaceutical dosage forms. Acta pharm Chromatographica. 2007; 18: 130-142.

6.       Jain D, Kachave RN, Bhadane RN. Simultaneous Estimation of Tramadol Hydrochloride, Paracetamol and Domperidone by RP-HPLC in tablet formulation. J Liq Chromatogr R T. 2010; 33: 786-792.

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8.       Prabu SL, Shirwaikar A, Shirwaikar A, Kumar CD, Joseph A, and Kumar R. Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method, Ind J  Pharm Sci, 2008; 70(1): 128–131.

9.       Zarapkar SS, Kanyawar NS. Simultaneous estimation of domperidone and omeprazole in pharmaceutical dosage by reverse phase high performance liquid chromatography. Ind Drugs. 2002; 39: 217–21.

10.     Pawar SM, Patil BS, Patil RY. Validated HPTLC method for simultaneous quantitation of Famotidine and Domperidone in bulk drug and formulation. Int J Adv Pharma sci. 2010; 1:54-59.

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