Author(s): Sarade A.N., Kalyane N.V., Shivkumar B.

Email(s): an.sarade@gmail.com

DOI: Not Available

Address: Sarade A.N., Kalyane N.V. and Shivkumar B.
Department of pharmaceutical chemistry, B. L.D.E.A’S college of Pharmacy, Bijapur, Karnataka, 586103. India
*Corresponding Author

Published In:   Volume - 4,      Issue - 5,     Year - 2011


ABSTRACT:
Antiviral, anti-inflammatory. Most potent is antimicrobial activity so we thought to synthesize some novel quinoline moiety incorporating with different aromatic and heterocyclic aldehydes moiety. The conventional methodology was adopted to synthesize the titled compound from starting material resorcinol and ethyl acetoacetate which is heated for 20min with conc. Sulfuric acid to give 7-hydroxy-4-methyl coumarine. The 4-(7-hydroxy-4-methyl-2-oxoquinolin- 1(2H)yl)benzene sulfonamide which is prepared by condensation of 7-hydroxy-4-methyl coumarine and sulphanilamide with glacial acetic acid for 6 hrs. and poured in to cold water, precipitate form. 4-(7-hydroxy-4-methyl- 2-oxoquinolin-1(2H)yl)benzene sulfonamide is further reacted with different substituted aromatic and heterocyclic aldehydes in presence of acetic acid as catalyst in ethanol by refluxing for 8 hr to yield the different derivatives of quinoline. The synthesized compounds were characterized by TLC, Melting point and spectral data. Melting points were determining by using precision melting point apparatus in open capillaries and are uncorrected. The purity of the compounds was checked by TLC, IR, 1H-NMR, Mass spectrum. The synthesized all quinoline derivatives were screened for anti bacterial activity.


Cite this article:
Sarade A.N., Kalyane N.V. , Shivkumar B. Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives. Research J. Pharm. and Tech. 4(5): May 2011; Page 827-831.


Recomonded Articles:

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Md Kamal Hossain, Kamrun Nahar, Parisa Shokryazdan, Norhani Abdullah, Kaiser Hamid, Mohammed Faseleh Jahromi

DOI: 10.5958/0974-360X.2017.00530.3         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): S. Krishnakumar, R. Divya, N.R. Kanchana Devi, G. Keerthana, A. Ancy Judi

DOI: 10.5958/0974-360X.2017.00234.7         Access: Open Access Read More

Author(s): Nadeem Siddiqui, Waquar Ahsan, M. Shamsher Alam, Andalip, Bishmillah Azad, M. Jawaid Akhtar

DOI: Not Available         Access: Open Access Read More

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags