Antiviral, anti-inflammatory. Most potent is antimicrobial activity so we thought to synthesize some novel quinoline moiety incorporating with different aromatic and heterocyclic aldehydes moiety. The conventional methodology was adopted to synthesize the titled compound from starting material resorcinol and ethyl acetoacetate which is heated for 20min with conc. Sulfuric acid to give 7-hydroxy-4-methyl coumarine. The 4-(7-hydroxy-4-methyl-2-oxoquinolin- 1(2H)yl)benzene sulfonamide which is prepared by condensation of 7-hydroxy-4-methyl coumarine and sulphanilamide with glacial acetic acid for 6 hrs. and poured in to cold water, precipitate form. 4-(7-hydroxy-4-methyl- 2-oxoquinolin-1(2H)yl)benzene sulfonamide is further reacted with different substituted aromatic and heterocyclic aldehydes in presence of acetic acid as catalyst in ethanol by refluxing for 8 hr to yield the different derivatives of quinoline. The synthesized compounds were characterized by TLC, Melting point and spectral data. Melting points were determining by using precision melting point apparatus in open capillaries and are uncorrected. The purity of the compounds was checked by TLC, IR, 1H-NMR, Mass spectrum. The synthesized all quinoline derivatives were screened for anti bacterial activity.
Cite this article:
Sarade A.N., Kalyane N.V. , Shivkumar B. Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives. Research J. Pharm. and Tech. 4(5): May 2011; Page 827-831.