Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

Email(s): sanjaybais@rediffmail.com

DOI: Not Available

Address: S.M. Charjan1*, S.K. Bais1, R.R. Shiradkar1, R.L. Bakal1, V.M. Durge2 and A.V. Chandewar1
1P.Wadhwani College of Pharmacy, Yavatmal-445001, India 2Varun Hospital, Arvi, Wardha, Yavatmal, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 5,     Year - 2011


ABSTRACT:
Metformin HCl is an oral anti-diabetic drug from the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function. Metformin is the most popular anti-diabetic drug in the India and one of the most prescribed drugs in the world. Ten brands (M1 to M10) of Metformin HCl tablets (850 mg) were evaluated for five in vitro parameters, both official and nonofficiali. viz; uniformity of weight, friability test, hardness test, thickness test and dissolution test. All the products met the requirements as per general specifications of Indian pharmacopoeia for tablet formulation. Drug content of all metformin tablets were within the range of 90% -110% of label claim.Dissoluiton profile was carried out, from the data it was noted that more than 97% drug release. The sample were then studied UV spectrophotometer at 233 nm for metformin HCL content. The release rate at different time interval were then determined. This sort of study is good indicator for the in vitro evaluation of idealness of commercial products. As per stability studies, there was no change or very slight change in the parameter studied for stability after first, second and third month of accelerated stability studies. Thus the formulation was found to be stable as per IP specification.


Cite this article:
S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar. Comparative Evaluation of Quality Control Parameters of Marketed Antidiabetic Tablet. Research J. Pharm. and Tech. 4(5): May 2011; Page 801-805.


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Fatemeh Abbasi, Malahat Nikravan Mofrad, Fariba Borhani, Malihe Nasiri

DOI: 10.5958/0974-360X.2017.00045.2         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mostafa Isbera, Ayat Abbood, Wehad Ibrahim

DOI: 10.5958/0974-360X.2016.00039.1         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags