Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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In-Vivo Antidiabetic, Lipid Lowering and Antioxidant Activities of Methanolic Extaract of Lawsonia inermis Leaves

Author(s): Chauhan H.V

Email(s): hvchauhan2006@rediffmail.com

DOI: Not Available

Address: Chauhan H.V.*
Sudhakarrao Naik Institute of Pharmacy, Pusad (MS)
*Corresponding Author

Published In:   Volume - 4,      Issue - 5,     Year - 2011

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ABSTRACT:
Present in-vivo study was carried out to evaluate the antidiabetic, lipid lowering and antioxidant activity of methanolic extract of Lawsonia inermis leaves in alloxan induced diabetic rats using glibenclamide (10mg/kg) as standard drug. Oral administration of methanolic extract of Lawsonia inermis leaves (600mg/kg body weight) for 14 days resulted in significant decrease in fasting blood glucose level (34.33%), serum triglycerides (43.35%), total cholesterol (34.18%), low density lipoprotein (11.05%), GOT (42.89%), and GPT (28.09%) with simultaneous increase in serum high density lipoprotein (50.48%) and serum glucokinase (208.75%). Further the methanolic extract of Lawsonia inermis leaves inhibited the generation of Malondialdehyd (TBARS) level (34.34%) in alloxan induced diabetic rats. The results of the present study demonstrate antidiabetic, lipid lowering and antioxidant activities in methanolic extract of Lawsonia inermis leaves, which could help in prevention of diabetic hyperlipedemia and related diseases.


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Cite this article:
Chauhan H.V. In-Vivo Antidiabetic, Lipid Lowering and Antioxidant Activities of Methanolic Extaract of Lawsonia inermis Leaves. Research J. Pharm. and Tech. 4(5): May 2011; Page 764-767.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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