Author(s): Arijit Das, Sibaji Ghosh, Sudip Das, Biplab Kr. Dey, Tarun Kanti Ghosh

Email(s): aridas009@gmail.com

DOI: Not Available

Address: Arijit Das1*, Sibaji Ghosh1, Sudip Das1, Biplab Kr. Dey1 and Tarun Kanti Ghosh2
1Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim-737136
2Regional institute of Pharmaceutical Science and Technology, Agartala, West Tripura- 799005
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
The aim of present research work was to prepare and evaluate transdermal drug delivery (TDDS) of metformin hydrochloride. Metformin hydrochloride is an agonist at a2 –adrenergic receptor sites. The drug undergoes rapid first pass metabolism (approximately 95% of dose) which necessitates its frequent dosing by oral route. Transdermal drug delivery system of metformin hydrochloride was prepared using combinations of a hydrophobic polymer, ethyl cellulose and hydrophilic polymer, polyvinyl pyrrolidone in different ratios (1:2, 1:4, 1:6, 1:8, 2:1, 4:1, 6:1 and 8:1 w/w) by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as plasticizer. The prepared polymeric films were characterized for various physiochemical parameters like film thickness, tensile strength, moisture content, moisture uptake, water vapour transmission rate. Permeation studies were carried out for patches through commercial semi-permeable membrane as well as mouse epidermis using Keshary-Chien diffusion cell. Formulation F6 showed 94.83% drug release from the patch within 24 h in in vitro diffusion cell and was selected for ex vivo skin permeation and drug release data of selected patch showed good fit into Higuchi equation. The effect of storage on in vitro release and physiochemical parameters of selected patch was found within the acceptable limits.


Cite this article:
Arijit Das, Sibaji Ghosh, Sudip Das, Biplab Kr. Dey, Tarun Kanti Ghosh. Formulation and In Vitro Evaluation of Transdermal Patches of Metformin Hydrochloride Using Hydrophilic and Hydrophobic Polymer Complex. Research J. Pharm. and Tech. 4(4): April 2011; Page 561-565.


Recomonded Articles:

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Author(s): Suresh V Kulkarni, Ranjit Kumar P, Nikunj Patel, Ramesh B, Someshwara Rao B, Ashok Kumar P

DOI: Not Available         Access: Open Access Read More

Author(s): Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Deepika Vashishth, Babar Ali, Rupinder Kaur

DOI: Not Available         Access: Open Access Read More

Author(s): Venkateswaramurthy N, Sambathkumar R, Vijayabaskaran M, Perumal P

DOI: Not Available         Access: Open Access Read More

Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

DOI: Not Available         Access: Open Access Read More

Author(s): Akelesh T., Sam Johnson, Udaya Chander J., Subhojit Samantha, Venkatanarayanan R.

DOI: 10.5958/0974-360X.2015.00268.1         Access: Open Access Read More

Author(s): Ujwala R. Bagmar, Dinesh C. Sancheti, Sarika R. Zade, Varsha K. Pawar, Nanda R. Badhe

DOI: Not Available         Access: Open Access Read More

Author(s): Sajid Ali, Maryam Shabbir, Muhammad Farooq, Sherjeel Adnan, Nabeel Shahid

DOI: Not Available         Access: Open Access Read More

Author(s): Shivhare UD, Kale MK, Bhusari KP, Madankar VS, Godbole MD

DOI:         Access: Open Access Read More

Author(s): Radhika PR, Luqman Moidutty, Borkhataria Chetan H

DOI:         Access: Open Access Read More

Author(s): Kothapalli LP, Mare SG, Thomas AB, Nanda RK, Deshpande AD

DOI:         Access: Open Access Read More

Author(s): K.B. Koteshwara, Anup Naha, Bishu Choubey

DOI: Not Available         Access: Open Access Read More

Author(s): UK Patil, Ravish Sahu, SK Yadav

DOI:         Access: Open Access Read More

Author(s): Shailesh Sharma, Sudhir Bharadwaj, G. D. Gupta

DOI:         Access: Open Access Read More

Author(s): YS Gattani, PS Kawtikwar, DM Sakarkar

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags