Author(s): V. Rajesh Babu, Aleem M.A, Syeda Rana Nikhat, Sana Aslam, Mohib Khan

Email(s): rajeshbabuvemula@gmail.com

DOI: Not Available

Address: V. Rajesh Babu*, Aleem M.A, Syeda Rana Nikhat, Sana Aslam and Mohib Khan
Faculty of Pharmacy, MESCO College of Pharmacy, Mustaidpura, Karwan Road, Hyderabad.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
Poorly water-soluble drugs often exhibit variable bioavailability and bio-inequivalence due to its poor water-solubility leading to hurdles in formulation development efforts. There are number of formulation approaches like micronisation, solubilization using cosolvents, precipitation techniques etc., to resolve the problems of low solubility and low bioavailability. Each of them have their own limitations. Other techniques like microemulsions, solid dispersions and inclusion complexes using cyclodextrins, even though showed increased solubility, are not applicable for drugs which are insoluble in both aqueous and organic media. The next development step is transformation of the micronized drug to drug nanoparticles and nanosuspensions. Nanoparticulate drug delivery system may offer plenty of advantages over conventional dosage forms which include improved efficacy, reduced toxicity, enhanced biodistribution and improved patient compliance. Nanosuspension technology offers novel solution for such poorly soluble drugs. Nanosuspension consists of pure poorly water soluble drugs with or without any matrix material suspended in dispersion and can be surfactant free or comprise of surfactants or stabilizers or both. Nanosuspensions differ from nanoparticles, which are polymeric colloidal carriers of drugs (Nanospheres and nanocapsules), and from solid-lipid nanoparticles (SLN), which are lipidic carriers of drug. This review focuses on characterization, properties, method of preparations, formulation considerations and various applications in drug delivery systems of nanosuspensions.


Cite this article:
V. Rajesh Babu, Aleem M.A, Syeda Rana Nikhat, Sana Aslam, Mohib Khan. Nanosuspension Technology for Poorly Water Soluble Drugs: An Overview. Research J. Pharm. and Tech. 4(4): April 2011; Page 515-520.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags