Any atom which consists of at least one unpaired electron in their outer most shell and also having the capability of independence existence can be defined as a free radical Due to the presence of unpaired electrons; the free radicals are very reactive. One of the most reactive oxygen radical was hydroxyl radical and it is consequently shot-term lived known radical. Hydroxyl radicals damages macro-molecules like DNA, in the lung epithelial cells. Within the cell, the hydroxyl radicals can upset the redox balance. So, in order to prevent these damages spin trapping is necessary. In this Review I will discuss how Nitroxides can acts as spin trapping agents and how these can be detected by various means.
Cite this article:
Sai Krishna Putta, Bala Krishna Talupula. Is it Possible to Trap –DNA Free Radicals Using Stable Nitroxides?. Research J. Pharm. and Tech. 4(4): April 2011; Page 499-501.