Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Evaluation of Protective Activity of Commelina benghalensis -Root Extracts Against Carbon Tetrachloride Induced Hepatic Toxicity in Wistar Rats.

Author(s): Sambrekar S.N., Patil P.A. and Kangralkar V.A

Email(s): Email ID Not Available

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Address: 1Dept of Pharmacology, Maratha Mandal’s College of Pharmacy, Belgaum, India. 2Joint Director, Research foundation, K.L.E. University Belgaum. 10

Published In:   Volume - 4,      Issue - 4,     Year - 2011

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ABSTRACT:
Root extracts of Commelina benghalensis was evaluated for hepatoprotective activity in Wistar rats. The root extract (200 mg/kg, p.o.) showed a significant (P<0.001) protection against carbon tetrachloride (CCl4) induced hepatotoxicity as judged by the estimation of serum markers and antioxidant enzymes levels. CCl4- increased significantly (P<0.001) aspartate amino transferase (AST), alanine amino transferase (ALT), bilirubin (total and direct), Malondialdehyde (MDA) while reduction in total protein, superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH). Rats treated with the root extracts (alcoholic and aqueous) showed significant (P<0.001) decrease in AST, ALT, MDA, bilirubin; and significant (P<0.001) increase in total proteins, SOD, GSH and CAT levels. The activity of alcoholic extract was found to be more significant than aqueous extract and almost equal to Liv52 in case of antioxidant enzymes estimation. Histopathological changes in hepatic tissues of all the treated groups provide protection against CCl4-induced hepatotoxicity.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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