Author(s): N.G. Raghavendra Rao, Upendra Kulkarni, Basawaraj S. Patil

Email(s): ngraghu@rediffmail.com

DOI: Not Available

Address: N.G. Raghavendra Rao1*, Upendra Kulkarni2 and Basawaraj S. Patil2
1PG. Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga- 585 103, Karnataka, India.
2Department of Pharmaceutics. RME’s College of Pharmacy, Gulbarga-585102, Karnataka, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
Cinnarizine is a piperazine derivative with antihistamine, sedative and calcium channel blocking activity. It is used for the systematic treatment of nausea and vertigo for the prevention and treatment of motion sickness. In the present invention Fast dissolving tablets of Cinnarizine were prepared by sublimation method. The prepared formulations were evaluated for pre-compressional and post-compressional parameters. The compatibility of drug with other ingredients was checked by FTIR and DSC studies, these results revealed that there was no interaction between dug and other excipients. The values of pre-compressional parameters were within prescribed limits and indicated good free flowing properties. In all the formulations the hardness test indicates good mechanical strength. Friability of all formulations was less than 1. Drug content was found to be high (= 101.50%) and uniform in all the formulations. The tablet thickness was found to be 3.59 – 3.62. The weight variation results revealed that average percentage deviation was less then ± 7.5 %, which provides good uniformity in all formulations. The disintegration time of the tablets decreased significantly with increase in the concentration of subliming agent. The formulations C4 50 % of drug released in 6.25 min, and 90 % of drug released in 19.74 min. Stability study carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets decreased significantly (p<0.05). The results concluded that fast dissolving tablets of Cinnarizine with sublimation technique, an optimum point can be reached in the shortest time with minimum efforts and this technique would be an effective alternative approach compared with the use of more expensive adjuvants in the formulations.


Cite this article:
N.G. Raghavendra Rao, Upendra Kulkarni, Basawaraj S. Patil. Design and Development of Fast Dissolving Cinnarizine Tablets by Sublimation Technique. Research J. Pharm. and Tech. 4(4): April 2011; Page 585-588.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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