Author(s): V.N Deshmukh, D.M. Sakarkar

Email(s): go2vilas@gmail.com

DOI: Not Available

Address: V.N Deshmukh* and D.M. Sakarkar
Sudhakarrao Naik Institute of Pharmacy, Pusad, 445204 (MS)
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
Mucoadhesive controlled release tablet can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, and allowing targeting and localization of a drug at a specific site. Mucoadhesive oral tablets were formulated by using model drug as Captopril and mucoadhesive polymers such as Carbopol 974P and Hydroxy propyl methylcellulose (HPMC K4 M and HPMC K15 M). The polymers were used in different concentrations to provided sustained release of drug over a period of 12 hr. along with mucoadhesion. Drug release from these tablets was diffusion controlled and followed non-Fickian release. Tablets also exhibited good swelling and mucoadhesive strength.


Cite this article:
V.N Deshmukh, D.M. Sakarkar. Development and Evaluation of Controlled Release Mucoadhesive Tablet. Research J. Pharm. and Tech. 4(4): April 2011; Page 578-581.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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