ABSTRACT:
The dosage uniformity of ayurvedic powders can be increased by formulating them in to tablets. In the present study, dispersible tablets of sudarshan, vyswanara and panchasakar churnas were prepared by wet granulation method. Initially sudarshan, vyswanara and panchasakar churnas were subjected to preformulation studies to test the suitability of direct compression method and was found that the results were not within the standard limits1. So wet granulation method was opted and appropriate formulations were developed. These tablets were evaluated for hardness, weight variation, friability, uniformity of dispersion, disintegration test, diameter of tablet, thickness of tablet, wetting time and stability studies. Here attempts were made to get minimum possible disintegration time by varying the concentrations of superdisintegrants like sodium starch glycolate (SSG), croscarmellose sodium (CCS) and crospovidone (CP) and usage of various diluents like lactose, insoluble starch powder, microcrystalline cellulose (MCC). It was found that concentration of CP at 20% w/w, MCC as diluent and poly vinyl pyrrolidone (PVP) as binder was highly effective in the formulation of dispersible tablets of sudarshan churna.