Vijabaskaran M, Senthilraja M, Babu G, Sajeer P
Vijayabaskaran M.*, Senthilraja M., Babu G. and Sajeer P.
Department of Pharmaceutical Chemistry, J.K.K Nataraja College of Pharmacy, P.Box.151, Natarajapuram, Salem Main Road, Komarapalayam, Namakkal District- 638183. Tamilnadu.
Volume - 4,
Issue - 3,
Year - 2011
A series of Schiff’s bases were prepared by the condensation of various aryl amines with hydroxy benzaldehyde in the presence of ethanol. The synthesized Schiff’s bases were converted to 2-azetidinone derivatives by reacting with triethylamine which is dissolved in dioxane and chloro acetyl chloride. The synthesized compounds were characterized on the basis of their elemental analysis and spectral data. Antimicrobial activities of the synthesized compounds were evaluated. The result reveals that the test compounds E and F exhibit good activity and remaining compounds show moderate anti-bacterial activity when compared to the standard drug Sparfloxacin.
Cite this article:
Vijabaskaran M, Senthilraja M, Babu G, Sajeer P. Synthesis and Evaluation of Schiff’s Bases and Their Azetidinone Derivatives for It’s Antibacterial Activity. Research J. Pharm. and Tech. 4(3): March 2011; Page 375-379.