D Saha, D Mridha, S Mondal, M Jana, S Kayal
D. Saha1*, D. Mridha2, S. Mondal2, M. Jana2 and S. Kayal3
1School of Pharmacy, Chouksey Engineering College, Bilaspur- 495004, C.G.
2Dept. of Pharmacy, Bharat Technology, Banitabla, Uluberia-711316, W.B.
3Dept. of Pharmacy, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela-769015, Orissa.
Volume - 4,
Issue - 3,
Year - 2011
The mechanisms by which organoselenium compounds inhibit tumor formation during the initiation phase of carcinogenesis have been explored in vitro and in well defined animal model. Various organoselenium compounds were found to have the ability to decrease lipids and phospholipids hydroperoxide levels, hydrogen peroxide, thereby destroying the propagation of free radicals; reactive oxygen and nitric oxide species mediating cellular damage. Organoselenium may inhibit oxidative stress to cells that produce toxicity and malignant transformation of cells leading to cancer. Organoselenium compounds have received wide attention as possible cancer chemopreventive agent.
Cite this article:
D Saha, D Mridha, S Mondal, M Jana, S Kayal. Organoselenium as a Cancer Chemopreventive Agent against Carcinogenesis. Research J. Pharm. and Tech. 4(3): March 2011; Page 367-368.