ABSTRACT:
Valsartan is an ACE inhibitor and effectively used in the treatment of hypertension. Valsartan is a poorly soluble drug, belonging to biopharmaceutical classification- II and dissolution is the rate limiting step for drug absorption. Valsartan fast dissolving tablets are formulated to overcome its poor solubility. Nature and concentration of the superdisintegrant and type of diluent influence the rate of dissolution. The present research focused the influence of concentration of the superdisintegrant and diluents on rate of drug release from the Valsartan fast dissolving tablets. The rate of drug release was found to be increased by increasing the concentration of the superdisintegrant and found to be highest for tablets formulated with Crospovidone 5%. The rate of drug release was found to be more for tablets formulated by spray dried lactose than compared to tablets formulated by Mannitol and Microcrystalline cellulose.
Cite this article:
A Pavan Kumar, J Satyanaryana, V Sai Kishore, TE Gopala Krishna Murthy. Formulation and Evaluation of Valsartan Fast Dissolving Tablets. Research J. Pharm. and Tech. 4(3): March 2011; Page 454-456.
Cite(Electronic):
A Pavan Kumar, J Satyanaryana, V Sai Kishore, TE Gopala Krishna Murthy. Formulation and Evaluation of Valsartan Fast Dissolving Tablets. Research J. Pharm. and Tech. 4(3): March 2011; Page 454-456. Available on: https://rjptonline.org/AbstractView.aspx?PID=2011-4-3-18