Author(s): Mallikarjuna Gouda M, Somashekar shyale, Putta Rajesh Kumar, SM Shanta kumar

Email(s): mkgouda0102@gmail.com

DOI: Not Available

Address: Mallikarjuna Gouda M.*, Somashekar Shyale , Putta Rajesh Kumar and S.M. Shanta Kumar
Department of Pharmaceutics and Pharmaceutical Chemistry, V. L. College of Pharmacy, Raichur, Karnataka, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2011


ABSTRACT:
Ciprofloxacin hydrochloride (CFH) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria used in ulcerative colitis and irritable bowel syndrome. A sensitive analytical UV spectrophotometric method was developed showed its absorption maxima at 271 nm in distilled water between 200 nm and 400 nm. Linearity studies indicated that estimation of CFH between 2.00 µg /ml to 10.00 µg /ml was found to be linear and obeyed beers law with regression equation of y = 0.0985*X 0.0004;( r2 = 0.9997). The low SD values of Inter day and Intra day variation studies indicated that the variation is minimum. The accuracy, precision studies showed that the recovery of drug from bulk fluids and dosage form are highly accurate and precise with minimum error. The above analytical parameters indicated that the developed UV Spectrophotometric method for CFH was simple, accurate, precise and reproducible for analysis of drug in different pharmaceutical dosage forms. Characterization studies showed that CFH melting point was 3240 C; the solubility studies indicated that, the drug is more soluble in water than in acidic or alkaline media. Further the log p value was observed as -0.538. The results showed that the methods used for drug characterization were simple with repeatable sensitivity.


Cite this article:
Mallikarjuna Gouda M , Somashekar shyale, Putta Rajesh Kumar, SM Shanta kumar. Analytical Method Development, Validation studies of a Fluoroquinolone chemotherapeutic antibiotic and its Characterization studies. Research J. Pharm. and Tech. 4(3): March 2011; Page 433-436.


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