M Umadevi, C Maheswari, R Jothi, Sai Kishore Paleti, Y Srinivasa Reddy, R Venkata Narayanan
M. Umadevi, C. Maheswari , R. Jothi, Sai Kishore Paleti, Y. Srinivasa Reddy, R. Venkata Narayanan:
R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, India.
Volume - 4,
Issue - 2,
Year - 2011
The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of flowers of Madhuca longifolia using paracetamol-induced liver damage in Wistar albino rats. Two doses of methanolic extract of Madhuca longifolia (100 and 200 mg/kg) were administered orally to the animals with hepatotoxicity induced by paracetamol (2 gm/kg). The methanolic extract showed significant (p<0.005) protective effect by lowering serum levels of various biochemical parameters such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase (ALP) and total bilirubin, and by increasing serum levels of total protein and albumin in the selected model. The biochemical observations were supplemented by histopathological examination of liver sections. The present study demonstrated the hepatoprotective activity of methanolic extract of M. longifolia validating the traditional use of flowers.
Cite this article:
M Umadevi, C Maheswari , R Jothi, Sai Kishore Paleti, Y Srinivasa Reddy, R Venkata Narayanan. Hepatoprotective Activity of Flowers of Madhuca longifolia (Koen.) Macbr. Against Paracetamol-Induced Hepatotoxicity. Research J. Pharm. and Tech. 4(2): February 2011; Page 259-262.