Author(s): A Suganthi, TK Ravi

Email(s): suganlemu@gmail.com

DOI: Not Available

Address: A. Suganthi* and T.K. Ravi
College of Pharmacy, SRIPMS, 395, Sarojini Naidu Road, Coimbatore-641044, Tamilnadu, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 2,     Year - 2011


ABSTRACT:
A simple, sensitive and precise RP-HPLC method was developed and validated for the determination of fenoverine (antispasmodic) in presence of its degradation products. Fenoverine and all the degradation products were resolved on a C18 column with the mobile phase composed of methanol, acetonitrile and 10mM ammonium formate (70:10:20, v/v/v) at 258 nm using a photodiode array detector. The method was linear over the concentration range of 5–50 µg mL–1 and precise with RSD < 2 % in intra- and inter-day study. Excellent recoveries of 100.57±1.692 to 101.40±0.6145 proved the accuracy of the method. Developed method was specific, as indicated by chromatographic resolution > 2.0 for each peak and sensitive with LOD 50 ng mL-1 and LOQ 0.5 µg mL–1. The method was used to study the drug degradation behavior under forced conditions. Two degradation products were formed during the degradation study in 6% H2O2 and water whereas only one degradation product in 1 mol L–1 HCl, 0.01 mol L–1 NaOH and photolytic degradation. The method was applied successfully for the assay of fenoverine in the capsule dosage form.


Cite this article:
A Suganthi, TK Ravi. Stability Indicating RP-HPLC Method for the Determination of Fenoverine in Bulk and Formulation. Research J. Pharm. and Tech. 4(2): February 2011; Page 237-241.


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