Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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A Validated RP-HPLC Method Development for Determination of Anthraquinone Marker from the Roots of Rubia cordifolia Linn.

Author(s): Khodke AS, Potale LV, Patole SM, Damle MC

Email(s): mcdamle@rediffmail.com

DOI: Not Available

Address: Khodke A.S., Potale L.V., Patole S.M., and Damle M.C.*
A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune - 411 001.
*Corresponding Author

Published In:   Volume - 4,      Issue - 2,     Year - 2011

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ABSTRACT:
Herbal medicines have good efficacy, safety, and lesser side effects. They are in great in demand in developed world for primary health care. India has rich traditional knowledge, heritage of herbal medicines and large biodiversity but despite it India has dismal share of world market. Many Pharma companies market herbal preparation as neutraceutical and take excuses from quality control parameter set by W.H.O. India has thousands of medicinal plants but in Indian Pharmacopoeia, Quality Control parameter of only 56 plants are included. Rubia cordifolia Linn has good pharmacological activity. Both stem and roots of Rubia cordifolia Linn have pharmacological activity. But in I.P. 2007, marker designation for stem of Rubia cordifolia Linn is included. Hence we have developed and validated HPLC method for marker isolated from roots of Rubia cordifolia Linn. Marker was isolated from roots Rubia cordifolia Linn and purified. RP- HPLC method for marker was developed using mobile phase Methanol: water in the ratio of 80:20. Stationary phase used for this method was Hi-Qsil C18 (250 × 4.6mm i.d.). Using this mobile phase marker gets eluted at RT 4.294. This RP-HPLC method was validated as per ICH guideline.


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Cite this article:
Khodke AS, Potale LV, Patole SM, Damle MC. A Validated RP-HPLC Method Development for Determination of Anthraquinone Marker from the Roots of Rubia cordifolia Linn. Research J. Pharm. and Tech. 4(2): February 2011; Page 326-328.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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