Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation and Evaluation of Instant Palatable Mouth Dissolving Tablets of Diphenhydramine HCl for Allergic Reactions - As Novel Approach

Author(s): Vaibhav Bande, S Senthil Kumar, K Sundaramoorthy, T Vetrichelvan

Email(s): vbande008@gmail.com

DOI: Not Available

Address: Vaibhav Bande*, S. Senthil Kumar, K. Sundaramoorthy and T. Vetrichelvan
Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319, Tamilnadu.
*Corresponding Author

Published In:   Volume - 4,      Issue - 2,     Year - 2011

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ABSTRACT:
Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. The investigation was undertaken with a view to develop fast dissolving tablets to get the quick onset of action in treatment of suddenly arising allergic reactions like urticaria, pruritis, angeoedema, bronchoconstriction and allergic rhinitis. An attempt has been made to study direct compression for formulation of mouth dissolving tablets of Diphenhydramine HCl. Total Nine formulations using various superdisintegrants namely Sodium starch glycollate, Crospovidone and Croscarmellose sodium were prepared. Taste inhibition has been achieved by using sensory approach. All prepared formulations were evaluated for physico-chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 20 to 35 sec. along with rapid in vitro drug release of 95% in first 15 minutes, it was concluded that the fast disintegrating /dissolving tablets of Diphenhydramine HCl can be made by direct compression technique using selective superdisintegrants showing quick onset of action followed by pleasant mouth feel, improved patient compliance and effective therapy.


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Cite this article:
Vaibhav Bande, S Senthil Kumar, K Sundaramoorthy, T Vetrichelvan. Formulation and Evaluation of Instant Palatable Mouth Dissolving Tablets of Diphenhydramine HCl for Allergic Reactions - As Novel Approach. Research J. Pharm. and Tech. 4(2): February 2011; Page 320-325.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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