M Kannadasan, Subal Debnath, Nilesh P Babre, P Parameshwar, VV Rajesham, Habibur rehman
M. Kannadasan1, Subal Debnath*2, Nilesh P. Babre2, P. Parameshwar2, V.V. Rajesham2 and Habibur rehman3
1College of Pharmacy, SRIPMS, Coimbatore, Tamilnadu.
2Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (mdl), Dist. Medak, Siddipet. Andra Pradesh – 502 277.
3PSG College of Pharmacy, Department of Pharmaceutics, Peelamedu, Coimbatore, T.N.
Volume - 4,
Issue - 2,
Year - 2011
The objective of the present study was to determine the anti-epileptic and behavioural studies of hydroalcoholic extract of the bark of Erythrina fusca Lour. (HAEEF). In the in vivo methods, whole animals are used for the demonstration of an injury by exogenous agents of epileptic seizure on the brain with its physiological significance. The anti-epileptic and behaviuoral studies of Erythrina fusca Lour. bark extract was studied by using different experimental models. Experimental models of epileptiform seizures (EMES) have constituted the nearest physiological approach to the development of new antiepileptic drugs for seizure control in epileptic patients. Epileptic seizure challenged animals treated with HAEEF at doses of 250 mg/kg and 500 mg/kg showed reduction MES-induced tonic phase latency and also inhibited the clonic seizure. Seizure duration was found to be lower in the extract treated animals than that shown by control group. Thus, it can be inferred that the hydro-alcoholic extract of Erythrina fusca Lour. bark possess antiepileptic effect against the animal models of epilepsy.
Cite this article:
M Kannadasan, Subal Debnath, Nilesh P Babre, P Parameshwar, VV Rajesham, Habibur rehman. Anti-Epileptic Activity of the Hydro-Alcoholic Extract of Erythrina fusca Lour. Bark through Behavioral Studies against the Animal Models of Epilepsy. Research J. Pharm. and Tech. 4(2): February 2011; Page 315-319.