Author(s): Kumud Gupta, Surendra Nath Pandeya, Ashish Kumar Pathak, Anuradha Gupta

Email(s): kumudgupta99@gmail.com

DOI: Not Available

Address: Kumud Gupta1, Surendra Nath Pandeya1, Ashish Kumar Pathak1 and Anuradha Gupta2
1Division of Medicinal Chemistry, Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow, Pin-226002, U.P., India.
2Division of Biotechnology (M.S. Pharm), National Institute of Pharmaceutical Edu. and Research (NIPER), Ahmedabad, C/O B. V. Patel PERD Centre, SG Highway, Thaltej, Ahmedabad, Pin- 380054, Gujarat
India
*Corresponding Author

Published In:   Volume - 4,      Issue - 2,     Year - 2011


ABSTRACT:
Ten Acyl hydrazine derivatives of ciprofloxacin were synthesized and evaluated for antibacterial activity in – vitro against Gram positive and Gram negative organisms. Among the synthesized compounds KSS3, KSS5, KSS7, KSS8, KSS9, were found to be the most active compounds with an MIC of 0.075 µg/ml against S. aureus, B. bronchiseptica, S. epidermis, E. coli, P. aeuroginosa and K. pneumoniae. These compounds were found to be 53.33 times more active as ciprofloxacin where as other five compounds KSS1, KSS2, KSS4, KSS6 and KSS10, were found to be 1.33 times more active as ciprofloxacin with an MIC of 3 µg/ ml. The results demonstrate the potential and importance of developing new quinolone derivatives against bacterial infection.


Cite this article:
Kumud Gupta, Surendra Nath Pandeya, Ashish Kumar Pathak, Anuradha Gupta, Synthesis and Antibacterial Activity of Ciprofloxacin Derivatives. Research J. Pharm. and Tech. 4(2): February 2011; Page 308-314.

Cite(Electronic):
Kumud Gupta, Surendra Nath Pandeya, Ashish Kumar Pathak, Anuradha Gupta, Synthesis and Antibacterial Activity of Ciprofloxacin Derivatives. Research J. Pharm. and Tech. 4(2): February 2011; Page 308-314.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2011-4-2-21


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DOI: 10.5958/0974-360X 

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