UK Karmakar, KS Rahman, NN Biswas, MA Islam, MI Ahmed, MC Shill, P Paul, M Kamruzzaman
U.K. Karmakar*, K.S. Rahman, N.N. Biswas, M.A. Islam, M.I. Ahmed, M.C. Shill, P. Paul and M. Kamruzzaman
Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
Volume - 4,
Issue - 2,
Year - 2011
The ethanolic extract of fruits of Trapa bispinosa Roxb (Family: Trapaceae) was screened for its antidiarrheal, analgesic and antioxidant activities. The fruit extract showed a significant (P<0.01) antidiarrheal activity against castor oil induce diarrhea in mice in which it decreased the frequency of defecation and increased the mean latent period at the dose of 500 mg/kg body weight. In acetic acid induced writhing test the extract, at the dose of 500 mg/kg, exhibited a maximum of 50.17% inhibition (P<0.01) of writhing reflex compared to the reference drug diclofenac sodium 55.22% (P<0.01). The antioxidant property of the extract was assessed by 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay. The extract showed antioxidant activity (IC50 about ~08 µg/ml) which was comparable to standard drug ascorbic acid (IC50 about ~10 µg/ml). The results tend to suggest that the extract might possess some chemical constituents that are responsible for antidiarrheal, analgesic and antioxidant activities.
Cite this article:
UK Karmakar, KS Rahman, NN Biswas, MA Islam, MI Ahmed, MC Shill, P Paul, M Kamruzzaman. Antidiarrheal, Analgesic and Antioxidant Activities of Trapa bispinosa Roxb. Fruits. Research J. Pharm. and Tech. 4(2): February 2011; Page 294-297.