As the end organ for the treatment of local diseases or as the route of administration for systemic therapies, the lung is a very attractive target for drug delivery. Pulmonary delivery of macromolecule provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorption of medication. Macromolecular Porous microparticle possess densities sufficient small to create aerodynamic particle sizes in the range of 1-5 µm, and for deep lung delivery 1-3 µm. To impart favorable aerodynamic properties, an effervescent technology provides encapsulate drug efficiently, sustained drug release, create porous scaffold for tissue engineering application.
Cite this article:
Pachoriya R, Sharma A. New Technologies in Particulate Engineering for Pulmonary Delivery of Macromolecule. Research J. Pharm. and Tech. 4(2): February 2011; Page 167-174.