Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation and Evaluation of Floating Pulsatile Microspheres of Aceclofenac for Rheumatoid Arthritis

Author(s): Jessy Shaji, Amol Shinde

Email(s): jshaji@rediffmail.com

DOI: Not Available

Address: Jessy Shaji * and Amol Shinde
K.M. Kundnani College of Pharmacy, 23, Jote Joy Building, Rambhau Salgaonkar Marg, Colaba, Mumbai-05.
Corresponding author

Published In:   Volume - 4,      Issue - 12,     Year - 2011

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ABSTRACT:
The purpose of present work is to develop microspheres for floating pulsatile release of aceclofenac intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The floating pulsatile microspheres were prepared by emulsion solvent diffusion technique. Polymers used for the preparation were Eudragit L100 and Eudragit S100 which gets solubilized at pH above 6 and 7 respectively. The floating microsphere provides two phase release pattern with initial lag time during floating in acidic medium followed by rapid release in phosphate buffer. This approach suggested the use of floating pulsatile microsphere as promising drug delivery for site and time specific release of aceclofenac for chronotherapy of rheumatoid arthritis.


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Cite this article:
Jessy Shaji, Amol Shinde. Formulation and Evaluation of Floating Pulsatile Microspheres of Aceclofenac for Rheumatoid Arthritis. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1877-1881.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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