Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Formulation and Evaluation of Floating Pulsatile Microspheres of Aceclofenac for Rheumatoid Arthritis

Author(s): Jessy Shaji, Amol Shinde

Email(s): jshaji@rediffmail.com

DOI: Not Available

Address: Jessy Shaji * and Amol Shinde
K.M. Kundnani College of Pharmacy, 23, Jote Joy Building, Rambhau Salgaonkar Marg, Colaba, Mumbai-05.
Corresponding author

Published In:   Volume - 4,      Issue - 12,     Year - 2011

 View HTML        View PDF

ABSTRACT:
The purpose of present work is to develop microspheres for floating pulsatile release of aceclofenac intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The floating pulsatile microspheres were prepared by emulsion solvent diffusion technique. Polymers used for the preparation were Eudragit L100 and Eudragit S100 which gets solubilized at pH above 6 and 7 respectively. The floating microsphere provides two phase release pattern with initial lag time during floating in acidic medium followed by rapid release in phosphate buffer. This approach suggested the use of floating pulsatile microsphere as promising drug delivery for site and time specific release of aceclofenac for chronotherapy of rheumatoid arthritis.


Keywords:

Cite this article:
Jessy Shaji, Amol Shinde. Formulation and Evaluation of Floating Pulsatile Microspheres of Aceclofenac for Rheumatoid Arthritis. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1877-1881.


Recomonded Articles:

Formulation and Evaluation of Diclofenac gel

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Formulation Development and Characterization of Etodolac Loaded Transethosomes for Transdermal Delivery

Author(s): S. B. Gondkar, Neha R. Patil, R. B. Saudagar

DOI: 10.5958/0974-360X.2017.00541.8         Access: Open Access Read More

Formulation, Characterization and In-vitro Evaluation of Abacavir Sulphate Loaded Microspheres

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Magnetic Nanoparticles: As a Drug Targeting Carrier

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

A Review on Floating Drug Delivery System of H2 Receptors

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Albumin Microspheres containing Stavudine

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

A Study on Efficacy and Safety of Etanercept in Patients with Rheumatoid Arthritis

Author(s): A. Chaitanya, M. Ashok Kumar, A. Gokul Krishna, P. Shanmugasundaram.

DOI: 10.5958/0974-360X.2016.00396.6         Access: Open Access Read More

Development and Optimization of Mucoadhesive Microsphere of Bovine Insulin

Author(s): Shinde AD, Bhise SB

DOI: Not Available         Access: Open Access Read More

Preparation and Evaluation of Mucoadhesive Microspheres Containing Heparin for Antiulcer Therapy

Author(s): Venkateswaramurthy N, Sambathkumar R, Vijayabaskaran M, Perumal P

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Extended Release Metformin Hydrochloride Microspheres by Ionotropic Gelation Technique

Author(s): Jain A.A., Panigrahy R.N., Mahale A. M.

DOI: Not Available         Access: Open Access Read More

Aceclofenac Extended Release Matrix Tablets: Formulation and In Vitro Evaluation

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Comparative Study on Anti-inflammatory and Analgesic Activities of Pure Aceclofenac with the Aceclofenac Loaded Mucoadhesive Microparticles in Rats

Author(s): Rajesh. M, Narayanan. N

DOI: 10.5958/0974-360X.2015.00033.5         Access: Open Access Read More

Simultaneous Estimation of Aceclofenac and Paracetamol in Bulk and Combined Tablet Dosage Form and From Biological Fluid by Planar Chromatography

Author(s): Poonam P. Patil, Mahesh M. Deshpande, Veena S. Kasture, Seema A. Gosavi

DOI:         Access: Open Access Read More

Self Emulsifying Drug Delivery System: A Novel Approach for Drug Delivery

Author(s): B Chengaiah, M Alagusundaram, S Ramkanth, C Madhusudhana Chetty

DOI: Not Available         Access: Open Access Read More

Identification and Characterization of Photoproduct Obtained By Photodegradation of Aceclofenac

Author(s): Nilesh Patel, Shailesh Shah, Ishwarsinh Rathod, Dhaval Patel, Biraju Patel

DOI: Not Available         Access: Open Access Read More

Controlled release Microcapsules for Oral Delivery of Aceclofenac: Formulation and Characterization

Author(s): Rajesh Palva, Sandeep Kumar Singh, Priya Ranjan Prasad Verma, Praveen R

DOI: 10.5958/0974-360X.2015.00042.6         Access: Open Access Read More

Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres

Author(s): Nighute AB, Bhise SB

DOI:         Access: Open Access Read More

A Novel Co-processed Super Disintegrating Agent Consisting of Crosspovidone and Sodium Starch Glycolate

Author(s): Shah Dhiren P, Jain Vineet C, Sonani Nitesh G, Dalvadi Hitesh P, Dhimmar Hiren D

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Pulsincap of Tramadol HCl for the Treatment of Rheumatoid Arthritis

Author(s): Mangesh A. Bhutkar, Swapna R. Khochage, Snehal D. Mali, Sadhana B. Todkar

DOI: Not Available         Access: Open Access Read More

Aceclofenac Loaded Vesicles: A Comparative Study between Various Vesicular Systems

Author(s): N. Madoria, M. Pathodiya, A. Tiwari

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats
Regulatory requirements for Post approval changes in Japan, Canada and Malaysia
Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats
Synthesis and Antibacterial activity of some newer Benzimidazole derivatives
The Correction Methods of the Intestinal Microflora in Chronic Colonic Stasis by Siphon Enema and Probiotics as a Means of the Hirschsprung-associated Enterocolitis Prevention
Stability Indicating HPTLC Determination of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations
Biochemical Evaluation of Antidiabetic properties of Strychnos potatorum Seeds extract studied in High Fat Diet Fed- Low dose Streptozotocin induced experimental type 2 diabetes in Rats
In Vitro Antioxidant and Antibacterial Screening of flowers Extract from Cassia auriculata Linn.
Preparation and Evaluation of Mouth Dissolving Tablets of Loratadine by Direct Compression Method
Phytochemical assessment and Bioactivity of alcoholic extract seed of Louranthus europpaeus
Design, Development and Evaluation of Solid Form of Liquid Self-Nanoemulsifying Formulation for improving the Oral Bioavailability of Itraconazole
Optimization and Characterization of Exopolysaccharide from Marine Soil Bacteria
Development and Validation of an RP-HPLC Analytical Method for Determination of Lisinopril in Full and Split Tablets
Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility
An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile
Synthesis, Characterization and Anti-oxidant Activity of Novel Phenylhydrazine derivatives containing carbonyl group on β- carbon
Pharmacognostical Evaluation and HPTLC Analysis of Two Medicinally important Secondary Metabolites in Bauhinia variegata Leaves from Gorakhpur District in Summer Season
Formulation, Characterization of Anticancer Nanoemulsion containing Trigonella foenum-graecum L. Seed oil
Endoscopic Retrograde Cholangiopancreatography in Central Iraq: A Retrospective Single- Center Study
Biosynthesis of Gold Nanoparticles using Leaf Extract of Desmodium gangeticum and their Antioxidant Activity

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 9821
Yesterday: 15043
Total: 1745687