Author(s): Minal Raghunath Narkhede, Bhanudas Shankar Kuchekar, Jitendra Yadav Nehete

Email(s): minalnehete@rediffmail.com

DOI: Not Available

Address: 1Department of Biopharmaceutics, Govt. College of Pharmacy, Karad, Dist-Satara (M.S.) 415124 (INDIA). 2Maharashtra Institute of Pharmacy, Pune-411038 (M.S) (INDIA). 3Department of Pharmacognosy, M.G.V’s Pharmacy College, Panchavati, Nasik 03.

Published In:   Volume - 4,      Issue - 12,     Year - 2011


ABSTRACT:
The aim of this study was to investigate the effect of presence of water soluble polymer, PVP K -25, PEG 6000 and HPMC, on complexation of felodipine with HP ß CD. Solid complexes at mole ratio 1:1 were obtained by freeze drying method. The phase solubility studies indicated the formation of HP- ß cyclodextrin complexes at a 1:1M ratio in solution, in presence and absence of water soluble polymers. All complexes were studied by X- ray diffractometry, Differential Scanning Calorimetry, FT-IR spectroscopy and dissolution study. X-ray diffraction data revealed decrement in crystallinity of binary and ternary systems. All DSC curves of binary and ternary systems showed shifting of characteristics melting peaks of pure drug. The process of felodipine complexation with HP ß CD, in presence of water soluble polymer was shown to involved aromatic ring, the carbonyl groups in ester bonds and carbon atom of DHP (dihydropyridine) linked via ester bonds. One of aim of complexation was to improve drug solubility and hence the dissolution rate of binary and ternary system tested. As result of inclusion complex formation, obtained by freeze drying method, brought dramatic 20 fold increase Felodipine solubility in presence of water soluble polymer HPMC. In photo-stability studies it is observed that upon inclusion complexation of felodipine with HP ß CD showed dramatic decreases in degradation rate constants and increases in the values of t0.1% .The possible reasons for protection of complexed felodipine against photo degradation could be due to inclusion of dihydropyridine ring into CD cavity where, dihydropyridine ring is involved in the first step of drug photo degradation. In docking of felodipine with cyclodextrin derivative(HPß CD), a hypothetical structures of complex also supported inclusion of dihydropyridine ring into CD cavity.


Cite this article:
Minal Raghunath Narkhede, Bhanudas Shankar Kuchekar, Jitendra Yadav Nehete. Ternary Systems of HP β-Cyclodextrin Felodipine Inclusion Complexes: Preparation, Characterization and Solubility Studies.


Recomonded Articles:

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Hemlata M. Nimje, Rajesh J. Oswal, Sandip S. Kshirsagar, Manoj Chavan

DOI: Not Available         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Nur Qistina Binti Ahmad Fauzi, Vishnupriya V, Gayathri R.

DOI: 10.5958/0974-360X.2016.00240.7         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Oruganti Sai Koushik, V. Himaja, P. Srinivasa Babu, Ramadoss Karthikeyan

DOI: 10.5958/0974-360X.2015.00298.X         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Author(s): Young-Hoon Lee, Su-Chul Han, Hong-Ryang Jung, Cheong-Hwan Lim

DOI: 10.5958/0974-360X.2017.00484.X         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Uday Gaikwad, Milind Parle

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags