Author(s): Supratim Ray

Email(s): supratimray_in@yahoo.co.in

DOI: Not Available

Address: Supratim Ray*
Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy and Allied Health Sciences, Bidhannagar, Durgapur, 713 206, India
Corresponding author

Published In:   Volume - 4,      Issue - 12,     Year - 2011


ABSTRACT:
The aim of the present work is to explore the utility of QSAR study on the in vitro antimycobacterial activities of N-Benzylsalicylamides and N-Benzylsalicylthioamides derivatives reported by Dolezal et al against Mycobacterium kansasii CNCTC My (235/80) using electrotopological state atom (E-state) parameter. The reported minimum inhibitory concentrations [MIC] of the compounds determined after 14 days of incubation. Different statistical tools used in this communication are stepwise regression analysis and partial least squares analysis (PLS). All the developed models indicate the importance of connecting moiety methylcarboxamido / methylthiocarboxamido group between two substituted phenyl groups. Based on internal validation (Q2), external validation (R2pred) PLS analysis was found to be the best model (Q2=0.595, R2pred=0.759).


Cite this article:
Supratim Ray. QSAR Modeling of Antimycobacterial Activities of N-Benzylsalicylamides and N-Benzylsalicylthioamides Derivatives against Mycobacterium kansasii CNCTC My (235/80) Using Topological Parameter. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1904-1909.


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DOI: 10.5958/0974-360X 

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