C. Maheswari, K. Meenakshi, P. Babu, R. Venkat Narayanan
C. Maheswari, K. Meenakshi, P. Babu and R. Venkat Narayanan
R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, India.
Volume - 4,
Issue - 12,
Year - 2011
Nephroprotective effect of flowers of Butea monospermia (BMF) against gentamycin-induced nephrotoxicity in male Wistar rats was assessed. Rats administered with gentamycin daily at 80 mg/kg i/p, for 9 days showed an significant increase in serum urea, serum creatinine and blood urea nitrogen and histopathological examination of kidney revealed extensive proximal tubular necrosis with marked glomerular changes. Methanol extract of Butea monospermia (BMF) at a dose rate of 100 mg/kg p.o. and 200 mg/kg p.o. showed a significant reduction in serum creatinine, blood urea nitrogen and serum urea levels. These effects were predominant with 200 mg/kg. In conclusion, our results suggest that BMF treatment reduces gentamicin-induced nephrotoxicity and this effect seems to be dose dependent.
Cite this article:
C. Maheswari, K. Meenakshi, P. Babu, R. Venkat Narayanan. Protective Effect of Butea monospermia Flowers Against Gentamycin Induced Renal Toxicity. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1898-1900.