Author(s): L. Satyanarayana, S.V. Naidu, M. Narasimha Rao, L. Rishi Priya, K. Suresh

Email(s): satyadna_l@yahoo.co.in

DOI: Not Available

Address: L. Satyanarayana1*, S.V. Naidu2, M. Narasimha Rao2, L. Rishi Priya1 and K. Suresh1
1Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy, Hyderabad-500 034.
2Centre for Biotechnology, Department of Chemical Engineering, College of Engineering (A), Andhra University, Vishakapatnam - 530003
*Corresponding Author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Entecavir in tablet dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5µm particle size, with mobile phase consisting of 0.02M Ammonium acetate in water and Acetonitrile in the ratio of 75:25 v/v was used. The flow rate was 0.7 ml/min and the effluents were monitored at 254 nm. The retention time was 3.853 min. The detector response was linear in the concentration of 40-120µg/ml. The respective linear regression equation being Y= 76650.808X – 34291.9 the limit of detection and limit of quantification was 0.05µg and 0.15µg/ml respectively. The percentage assay of Entecavir was 98.74%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Entecavir in bulk drug and in its pharmaceutical dosage form.


Cite this article:
L. Satyanarayana, S.V. Naidu, M. Narasimha Rao, L. Rishi Priya, K. Suresh. The Estimation of Entecavir in Tablet Dosage Form by RP-HPLC. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1699-1701.


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