Author(s): Keshav R. Deshmukh, Alok Pandey, Ashish Pandey, Vidyanand Patel, Shekhar Verma, Pramod Dewangan, Ghanshyam Deshmukh

Email(s): keshdesh@yahoo.com

DOI: Not Available

Address: Keshav R. Deshmukh1*, Alok Pandey1, Ashish Pandey1, Vidyanand Patel1, Shekhar Verma1, Pramod Dewangan2 and Ghanshyam Deshmukh3
1Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur – 492101, (C.G.)
2Royal College of Pharmacy, Mahoba Bazar, Raipur- 492001. (C.G.)
3Ranbaxy Labs Pvt. Ltd. Dewas (M.P.)
*Corresponding Author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
The aim of the current study was to design mouth dissolving tablets of loratadine and to optimize the drug dissolution profile by modifying the carrier concentration. Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. The present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, loratadine, by a solid dispersion technique. Solid dispersions were prepared using polyethylene glycol 6000 (PEG 6000) and polyvinylpyrrolidone K30 (PVP K30) in different drug-to-carrier ratios by solvent evaporation method. These new formulations were characterized in the liquid state by solubility studies and in the solid state by differential scanning calorimetry (DSC) and FTIR spectroscopy. The aqueous solubility of loratadine was favored by the presence of both polymers. In contrast to the very slow dissolution rate of pure loratadine, the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Solid dispersion prepared with PEG showed the most improvement in wettability and dissolution rate of loratadine. Mouth dissolving tablets prepared of loratadine solid dispersion were using superdisintegrants like crospovidone, sodium starch glycolate and cross carmellose sodium by direct compression method. The prepared tablets were evaluated for uniformity of weight, tensile strength, content uniformity, hardness, friability, wetting time, and in vitro dispersion time.


Cite this article:
Keshav R. Deshmukh, Alok Pandey, Ashish Pandey, Vidyanand Patel, Shekhar Verma, Pramod Dewangan, Ghanshyam Deshmukh. Design and Development of Loratadine Containing Mouth Dissolving Tablets. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1676-1681.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Kuldeep Malodia, Sunil Kumar, Pankaj Rakha, SK Singh, DN Mishra

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags