Nirmala Gupta, R.C. Agrawal, Vinoy Shrivastava, Amit Roy, Pushpa Prasad
Nirmala Gupta1*, R.C. Agrawal1, Vinoy Shrivastava2, Amit Roy3 and Pushpa Prasad3
1Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
2Dept. of Biosciences, Barkatullah University, Bhopal (MP), India
3Columbia Institute of Pharmacy, Raipur
Volume - 4,
Issue - 11,
Year - 2011
The aim of the present study was to investigate the protective efficacy of hydromethanolic fruit extract of Aegle marmelos on Cyclophosphamide (CP) induced micronuclei (MN) formation in bone marrow cells of mice. Swiss albino mice were treated with a single i.p. dose of 450, 675 and 900 mg/kg b.w. with Aegle marmelos fruit extract prior to CP administration. The result demonstrated that the micronuclei frequencies gradually decreased with increase in concentration of the extract suggesting a protective effect and the extract alone had not induced MN formation, reiterating the fact that the extract has no pro-mutagenic components.
Cite this article:
Nirmala Gupta, R.C. Agrawal, Vinoy Shrivastava, Amit Roy, Pushpa Prasad. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1666-1668.