D. Maheswara Reddy, Y. Krishna Reddy, D. Rajasekhar Reddy, N. Vinay Kumar, M.Suresh, Mogal Althaff, Naveen Kumar Valaparla
D. Maheswara Reddy*, Y. Krishna Reddy, D. Rajasekhar Reddy, N. Vinay Kumar, M.Suresh, Mogal Althaff and Naveen Kumar Valaparla.
Sri Vani School of Pharmacy, Chevuturu, G.Konduru (M), Krishna (Dt),
Volume - 4,
Issue - 11,
Year - 2011
Ciprofloxacin hydrochloride is a fluoroquinolone anti infective agent useful in the treatment of eye infections such as conjunctivitis, Keratitis and keratoconjunctivitis. Ciprofloxacin hydrochloride ocuserts were prepared using different polymers in various proportions and combinations such as Poly vinyl alcohol (PVA), Hydroxy propyl methyl cellulose (HPMC), methyl cellulose ( MC) and Hydroxy ethyl cellulose (HEC) by casting method with aim of increasing the contact time, achieving sustained release, reduction in frequency of administration, improving patient compliance and therapeutic efficacy. Here I am using hydroxyl methyl cellulose is 15cps grade, methyl cellulose is low viscosity and poly vinyl alcohol is warm water soluble. The physico-chemical parameters of the prepared ocuserts were evaluated for moisture absorption, moisture loss, thickness, weight variation, folding endurance, surface pH, sterility test and ocular irritation studies. The In vitro drug release were studied using bovine cornea (semi permeable membrane) Franz diffusion cell and check the absorbance maximum at 274nm. A zero order release formulation FD2 is sterilized by exposing UV radiation and subjected to In vivo studies. Ocular toxicity was also carried out for the formulation FD2. IR spectral observation show there is no interaction of drug with polymer which indicates the intactness of drug in formulation.
Cite this article:
D. Maheswara Reddy, Y. Krishna Reddy, D. Rajasekhar Reddy, N. Vinay Kumar, M.Suresh, Mogal Althaff, Naveen Kumar Valaparla. Formulation and Evaluation of Ciprofloxacin Ocuserts. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1663-1665.