Author(s): P. B. Patil, A. A. Hajare, R. P. Awale

Email(s): aahajare@rediffmail.com

DOI: Not Available

Address: P. B. Patil, A. A. Hajare* and R. P. Awale
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Dist-Kolhapur (M. S.), 416013
Corresponding author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
Extended release press coated tablets of Mesalamine were designed with hydrophilic HPMC and enteric coated eudragit S-100 polymer. Combinations of hydrophilic polymers such as HPMC K4M, HPMC E5 and enteric coated eudragit S-100 polymers were used in different concentrations to formulate colon release tablets for giving the release of Mesalamine. Tablets of Mesalamine were prepared by direct compression using combined pH and time dependent approach and subjected to in vitro drug dissolution for 12h by using USP Type-II dissolution apparatus at speed of 100rpm at a temperature of 37 ± 0.5°C using simulated gastric fluid 900mL 0.1N HCl (pH 1.2) and Phosphate buffer pH 6.8 and 7.2. The combination of HPMC K4M: HPME E5 (70:30 %) with 8 % enteric coat of Eudragit S 100 were the optimum concentrations exerting lag time of 6 h. The PX-RD studies on optimized batch revealed amorphous nature. The DSC thermogram indicates no any interaction between drug and polymer. The absence of drug release during first 6 h is the lag period of 6 h that can be sufficient for delivery of Mesalamine in to the large intestine. Mesalamine press coated enteric coating tablet formulation may consecutively enhance the lag period and residence time of the drug in the colon and thus may potentiate its anti-inflammatory action.


Cite this article:
P. B. Patil, A. A. Hajare, R. P. Awale. Development and Evaluation of Mesalamine Tablet Formulation for Colon Delivery. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1751-1756.


Recomonded Articles:

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): A. Khuntia, S.K. Mohanty

DOI: Not Available         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Zain Mhanna, Wehad Ibrahim, Tamim Hammad

DOI: 10.5958/0974-360X.2016.00040.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags