Author(s): S.B. Bhanja, S.K. Martha, P.K. Sahu, A. Sahu, B.B. Panigrahi, N. Shukla

Email(s): satyabrata_bhanja@rediffmail.com

DOI: Not Available

Address: S.B. Bhanja1*, S.K. Martha1, P.K. Sahu1, A. Sahu1 B.B. Panigrahi2 and N. Shukla3
1Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore (K), Odisha.
2Hi-Tech College of Pharmacy, Bhubaneswar, Odisha
3Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Odisha
Corresponding author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
Nicardipine Hydrochloride microcapsules with a coat consisting of Cyclohexane and a polymer such as Ethyl cellulose were prepared by Coacervation phase separation induced by temperature change method. By Scanning Electron Microscopy, the microcapsules were found to be spherical, without aggregation, discrete and free flowing. The maximum percentage of drug content was found to be 85.4 % in formulation F1 in the drug: polymer ratio (4:1). Entrapment efficiency were found to be in the range of 82 % to 106%. The average particle size was found to be in the range of 222 µm to 389µm. Percent of loose drug on surface were found to be in the range of 4.54% to 8.76%. All the formulations showed good flowability. The in-vitro drug release for all the formulations F1 to F9 were found to be 6.9% to 18.4% drug release in first hour and 55.9 % to 98.8% drug release at the end of 12 hrs. Among the nine formulations, F7 shows maximum drug release i.e. 98.8% at the end of 12 hrs. All the formulations F1 to F9 were found to be Zero order drug release with Non Fickian diffusion mechanism. The FTIR study indicates that there was no drug interaction and compexation occur during the manufacturing process.


Cite this article:
S.B. Bhanja, S.K. Martha, P.K. Sahu, A. Sahu, B.B. Panigrahi, N. Shukla. Preparation and In-Vitro Evaluation of Nicardipine Hydrochloride Microcapsules. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1737-1741.


Recomonded Articles:

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Baviskar Anagha, Hiremath Shivanand, Akul Manoj, Pawar Poonam

DOI: Not Available         Access: Open Access Read More

Author(s): Zain Mhanna, Wehad Ibrahim, Tamim Hammad

DOI: 10.5958/0974-360X.2016.00040.8         Access: Open Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): Thulasi V. Menon, C.I. Sajeeth

DOI: Not Available         Access: Open Access Read More

Author(s): Gupta Khemchand, Singhvi I., Ashawat M.S., Gupta Santosh Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Vijay Shinde, P Amsa, S Tamizharasi, D Karthikeyan, T Sivakumar, Aniket Kale

DOI: Not Available         Access: Open Access Read More

Author(s): Rajesh Palva, Sandeep Kumar Singh, Priya Ranjan Prasad Verma, Praveen R

DOI: 10.5958/0974-360X.2015.00042.6         Access: Open Access Read More

Author(s): N. Madoria, M. Pathodiya, A. Tiwari

DOI: Not Available         Access: Open Access Read More

Author(s): Satheesh babu N., Prabakaran L., Gowthamarajan K.

DOI: Not Available         Access: Open Access Read More

Author(s): G.V. Wadageri, S.A. Raju, S.B. Shirsand, P. Vijay Prakash Reddy

DOI: Not Available         Access: Open Access Read More

Author(s): Satyabrata bhanja, K. Lakshmi Deepthi, Muvvala Sudhakar, Bibhuti Bhusan Panigrahi

DOI: Not Available         Access: Open Access Read More

Author(s): Radhika PR, Luqman Moidutty, Borkhataria Chetan H

DOI:         Access: Open Access Read More

Author(s): Sonia Singh1*, Umesh D. Shivhare2 and S. N. Sakarkar1

DOI: Not Available         Access: Closed Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags