Author(s): Pramod S. Salve

Email(s): pramodsalve77@yahoo.com

DOI: Not Available

Address: Pramod S. Salve*
University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University
Campus, Mahatma Fuley Shaikshanik Paisar, Amravati Road, Nagpur- 440 033 (MS) India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011


ABSTRACT:
Oral bioavailability of drugs is significantly low due to poor solubility. Approximately 40% of newly discovered drugs are poorly water soluble. To increase the bioavailability, various approaches like inclusion complexes, co solvents, hydrotropism etc. are used. In the lipid formulation of self emulsifying drug delivery system (SEDDS) utilizes the concept of drug solubilisation in situ when it comes in contact with aqueous media. The lipid SEDDS utilizes soft or hard gelatin capsules for filling of solubilized drug which shows problems of drug leakage, incompatibility etc. Telmisartan indicated for the treatment of hypertension was used as a model poor water soluble drug. Bioavailability of telmisartan is 40-52%. SEDDS were prepared for telmisartan using Captex355, Capmul MCM C8, and Tween 80. The ternary phase diagram were plotted to optimized the proportions of oil (10-50), surfactant (0-90) and co surfactant (0-90) The optimum amount of three agents leading to enhanced solubility was used. The solubilised drug was then adsorbed on the carrier made up of aluminium magnesium silicate and other diluents like flowac, MCC PH101. The physicochemical characterization of solubilised system for visual isotropy, self emulsification time, emulsion droplet size and similarly powder flow analysis of the adsorbed solubilised system on the carrier was done. In vitro drug release studies were carried out in pH 6.8 phosphate buffer. The SEDDS has shown nanoscale droplet size and total clarity on dilution with water. It has also shown good flowing properties. A complete drug release was observed within a period of 5-25 minutes. Hence the problem of efficiently delivering poorly soluble drugs would be solved by solid SEDDS.


Cite this article:
Pramod S. Salve. Optimization of Variables for Solid Self Emulsifying Drug Delivery System for Insoluble Drug. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1581-1587.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags