Mohit Batra, Rahul Nainwani, Nitin Mishra, Pradeep Guleria, Amit Jain
Mohit Batra*, Rahul Nainwani, Nitin Mishra, Pradeep Guleria and Amit Jain
Department of Pharmaceutics, Mahatma Gandhi College of Pharmaceutical Sciences, Sitapura, Jaipur (Raj.)
Volume - 4,
Issue - 10,
Year - 2011
Dendrimer is described as NANO-DEVICE, with a regular and highly branched three dimensional architecture. They consist of three major architectural components: core, branches, and end groups. First discovered in the early 1980’s by Donald Tomalia. A dendron usually contains a single chemically addressable group called the focal point.These hyperbranched molecules were called dendrimers Dendritic molecules are characterized by structural perfection. At the same time, Newkome’s group independently reported synthesis of similar macromolecules. They called them arborols from the Latin word ‘arbor’ also meaning a tree. The uniqe properties of dendrimers such as uniform size, high degree of branching, water solubility, multivaelency, well defined molecular weight it’s important for biological activity and drug delivery application. These properties are important in pharmaceutical, nano technology and medicinal chemistry particularly. In addition nano particles drug delivery systems are the popular once as are able to increase selectivity and stability of therapeutic agents.
Cite this article:
Mohit Batra, Rahul Nainwani, Nitin Mishra, Pradeep Guleria, Amit Jain. Dendrimers as Therapeutic Nano-Devices: A Review. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1533-1541.