Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

Email(s): abhi_pharma007@yahoo.com

DOI: Not Available

Address: Karanje Abhijit Sampatrao1, Kandale Jitendra Bhalchandra*, Jadhav Ravindra2, Patil Manohar3
1Allana College of Pharmacy, Azam Campus, Camp, Pune.
2Deputy General Manager, M. J. Biopharm Pvt. Ltd. Taloja Navi-Mumbai.
3M. MS. College of Pharmacy, Thergaon, Chinchwad, Pune.
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011


ABSTRACT:
The present work represents topical gel formulation of Silymarin obtained from the seeds of plant Silybum marianum (L.) Silymarin is mixture of flavolignan. It consists of silybinin, silydianin, silychristin and isosilybinin. Silymarin is used as Hepatoprotective from ancient time apart from it is used as antioxidant, anti-inflammatory, anti-fibrotic, immunomodulatory and liver regenerating action. It also used clinically in liver disease, viral hepatitis, amanita mushroom poisoning, neuroprotective and neurotropic action. The various formulation of silymarin is available like tablet, capsule, suspension, syrup in market. The present aim of the study to develop silymarin gel and check antifungal activity. By using methanol as co-solvent and the Carbopol is used as gel forming agent and methyl Paraben and Propyl Paraben as preservative. The glycerin as humectants and Tween 80 used as surfactant. Gel are subjected to various physicochemical parameters such as pH, drug content, spreadability, viscosity, in vitro drug release was carried out in phosphate buffer (pH 6), primary skin irritation test and antifungal activity was checked. The stability study was done as per the ICH guidelines. The drug content, pH, spreadability of the formulation was found to be 96.6%, 6.8, 25.45gm.cm/sec respectively. From the rheogram it is concluded that gel shows pseudoplastic flow property. It shows maximum drug release 96.30% over a period of 3h.The formulation did not show acute skin irritancy.


Cite this article:
Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar. Formulation Development and Evaluation of Silymarin Gel. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1633-1636.


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta

DOI: 10.5958/0974-360X.2017.00425.5         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Amurdhavani. B.S

DOI: 10.5958/0974-360X.2016.00299.7         Access: Closed Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Amina Mehrin Bano, Vishnupriya. V, Gayathri. R

DOI: 10.5958/0974-360X.2016.00171.2         Access: Open Access Read More

Author(s): G. Bhavani, R. Navaneethan

DOI: 10.5958/0974-360X.2017.00269.4         Access: Open Access Read More

Author(s): P.Maheshwari, D.Pavithra, Neethu.T.T, T.S. Shanmugarajan, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00011.7         Access: Open Access Read More

Author(s): Bhawna Goyal, Sunil Agrawal, B.S. Sohi, Ayush Dogra

DOI: 10.5958/0974-360X.2016.00176.1         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): Fatemeh Abbasi, Malahat Nikravan Mofrad, Fariba Borhani, Malihe Nasiri

DOI: 10.5958/0974-360X.2017.00045.2         Access: Open Access Read More

Author(s): Aadil Ahamed.S, Dhanraj. M

DOI: 10.5958/0974-360X.2017.00169.X         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags