Vengadesh Prabhu K., Sundaramoorthi C, Selvaraju K., Karthick K., Beena K.P.
Vengadesh Prabhu K.1*, Sundaramoorthi C1, Selvaraju K.2, Karthick K. 2 and Beena K.P.3
1Department of Pharmaceutical Biotechnology, KMCH College of Pharmacy, Coimbatore-48, India.
2Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore-48, India.
3Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore-48, India.
Volume - 4,
Issue - 10,
Year - 2011
The goal of this study was to evaluate the technological feasibility of delivering antigen using chitosan microspheres. The microspheres were prepared by a mild and simple but effective adsorption method. Process parameters were analyzed in order to optimize the drug loading and release profiles. Scanning electron microscopy permitted a structural analysis. All microspheres were spherical and smooth with the mean particle size in the range was 20µm. The encapsulation efficiency of bovine serum albumin (BSA), chosen as model antigen, Bio distribution studies indicated that the degree of uptake by the M-cells of the peyer’s patches in the gut was higher than that of the other organs. Therefore, chitosan microspheres appear, technologically, a promising antigen delivery system.
Cite this article:
Vengadesh Prabhu K., Sundaramoorthi C, Selvaraju K., Karthick K., Beena K.P. Preparation and Characterization of Chitosan Microspheres Containing a Model Antigen. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1630-1632.