Lalit Singh, Arun Nanda, Bhupinder Singh, Saurabh Sharma
Lalit Singh1*, Arun Nanda2, Bhupinder Singh3, Saurabh Sharma4
1Department of Pharmaceutics, SRMSCET, PHARMACY Bareilly, Uttar Pradesh, India
2Department of Pharmaceutical sciences MDU, Rohtak, Haryana, India
3UIPS, Punjab University, Chandigarh, India
4Faculty of Pharmacy, VCTE, Bijnor, Uttar Pradesh, India
Volume - 4,
Issue - 10,
Year - 2011
Oral bioavailability of some drugs can be limited by the residence time of pharmaceutical formulation in the upper gastrointestinal tract. Gastric emptying plays an important role in the dynamics of drug absorption and can lead to variable and unpredictable bioavailability. And it becomes more critical for drugs which are exclusively absorbed in the upper small intestine or in a limited segment of the intestine “regional absorption”. To overcome this restriction and to increase the bioavailability of these drugs, controlled drug delivery systems with a prolonged residence time in the stomach can be used. Approaches for achieving prolonged residence times of the devices in the upper part of the gastrointestinal tract include the use of bio-adhesive, size increasing, and floating drug delivery systems.
Cite this article:
Lalit Singh, Arun Nanda, Bhupinder Singh, Saurabh Sharma. Drug Delivery Technologies for Upper Small Intestinal Window: A Review. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1499-1505.