Author(s): Theivendren Panneer Selvam, Palanirajan Vijayaraj Kumar

Email(s): tpsphc@gmail.com

DOI: Not Available

Address: Theivendren Panneer Selvam1* and Palanirajan Vijayaraj Kumar2
1Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510,
Andhrapradesh, India. 2School of Pharmacy, UCSI University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia.
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011


ABSTRACT:
As series of heterocycles, 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline 6a-o derivatives were synthesized and tested for Antihyperglycemic activity. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. All the newly synthesized compounds chemical structures were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analyses. The results of studies indicate that the compounds 6a, b, d, j, o displayed signi?cant reduction in blood glucose level in streptozotocin and sucrose loaded rat models.


Cite this article:
Theivendren Panneer Selvam, Palanirajan Vijayaraj Kumar. Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues. Research J. Pharm. and Tech. 4 (1): January 2011; Page 66-71.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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