Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues

Theivendren Panneer Selvam; Palanirajan Vijayaraj Kumar

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues

Author(s): Theivendren Panneer Selvam, Palanirajan Vijayaraj Kumar

Email(s): tpsphc@gmail.com

DOI: Not Available

Address: Theivendren Panneer Selvam1* and Palanirajan Vijayaraj Kumar2
1Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510,
Andhrapradesh, India. 2School of Pharmacy, UCSI University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia.
*Corresponding Author

Published In: Volume - 4, Issue - 1, Year - 2011

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ABSTRACT:
As series of heterocycles, 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline 6a-o derivatives were synthesized and tested for Antihyperglycemic activity. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. All the newly synthesized compounds chemical structures were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analyses. The results of studies indicate that the compounds 6a, b, d, j, o displayed signi?cant reduction in blood glucose level in streptozotocin and sucrose loaded rat models.

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Cite this article:
Theivendren Panneer Selvam, Palanirajan Vijayaraj Kumar. Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues. Research J. Pharm. and Tech. 4 (1): January 2011; Page 66-71.

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