Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Anti-Ulcer Activity of Crude Alcoholic Extract of Rhizomes of Cissus repens Lan.

Author(s): Umbare RP, Mate GS, Dongare SS

Email(s): ramumbare1402@gmail.com , ramumbare1402@rediffmail.com

DOI: Not Available

Address: Umbare R.P.*, Mate G.S. and Dongare S.S.
A.S.P.M’s K.T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, (M.S.), India- 413501.
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011

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ABSTRACT:
The present study was designed to evaluate the effects of ethanol extract of Cissus repens Lan against experimentally induced gastric ulcers. It is evaluated for its anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer (antisecretory), HCl–ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Cissus repens Lan extract at a dose of 300 mg/kg p.o. markedly decrease the incidence of ulcers in all the three models. Ethanol extract of Cissus repens Lan showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. The plant extract also showed gastro protective activity (49.65%), whereas standard drug sucralfate showed 90.49%. Cissus repens Lan extract showed protection index 39.0% in water immersion stress induced ulcer, whereas standard drug omeprazole showed protection index 98%.


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Cite this article:
Umbare RP, Mate GS, Dongare SS. Anti-Ulcer Activity of Crude Alcoholic Extract of Rhizomes of Cissus repens Lan. Research J. Pharm. and Tech. 4 (1): January 2011; Page 60-62.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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