Author(s): A.V. Yadav, M.N. Urade

Email(s): mukund_urade@rediffmail.com

DOI: Not Available

Address: A.V. Yadav1 and M.N. Urade2*
1Gourishankar Institute of Pharmaceutical Education and Research, A/P: Limb, Dist: Satara, Maharashtra, India – 415015.
2Shree Santkrupa College of Pharmacy, A/P: Ghogaon, Tal: Karad, Dist: Satara, Maharashtra, India – 415111.
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
The purpose of this research was to develop and evaluate mucoadhesive buccal films containing Venlafaxine hydrochloride using Chitosan as base matrix. The buccal films were prepared by solvent casting technique. Different ratios of PVP K-30 were incorporated into the films to improve drug release properties of the films. The films were evaluated for their physical characteristics like weight, drug content, surface pH, swelling index, folding endurance, Ex Vivo mucoadhesion time, in Vitro drug release and FT-IR studies. Films exhibited sustained release over a period of 6 hours. The mechanism of drug release was found to be Non-fickian diffusion. Addition of PVP K-30 generally enhanced release rate. Films were having weight in the range of 146.67 + 3.18 to 165.67 + 2.6 mg. Swelling index was proportional to PVP K-30. Ex vivo mucoadhesion time was in the range of 142 to 287 minutes. The surface pH of all films was within limit (7.0), hence films would not cause irritation in the buccal cavity. Results indicate that these buccal films are adequate for the systemic delivery of venlafaxine hydrochloride.


Cite this article:
A.V. Yadav, M.N. Urade. Preparation and Evaluation of Chitosan Containing Mucoadhesive Buccal Films of Venlafaxine Hydrochloride. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1213-1217.


Recomonded Articles:

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Nur Qistina Binti Ahmad Fauzi, Vishnupriya V, Gayathri R.

DOI: 10.5958/0974-360X.2016.00240.7         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Oruganti Sai Koushik, V. Himaja, P. Srinivasa Babu, Ramadoss Karthikeyan

DOI: 10.5958/0974-360X.2015.00298.X         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Author(s): Young-Hoon Lee, Su-Chul Han, Hong-Ryang Jung, Cheong-Hwan Lim

DOI: 10.5958/0974-360X.2017.00484.X         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Uday Gaikwad, Milind Parle

DOI: Not Available         Access: Open Access Read More

Author(s): Saleem M.A., Sudhir S. Pange, Shaikh Ahnaf Umair, Vishal Kumar Singh

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags