Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablet of Ranitidine Hydrochloride.

Author(s): Jagtap P.C., Awargaonkar A.V., Kuchekar S.B., Bhise K.S.

Email(s): ksbhise@rediffmail.com

DOI: Not Available

Address: Jagtap P.C., Awargaonkar A.V., Kuchekar S.B. and Bhise K.S.*. Department of Pharmaceutics, MCE Society’s Allana College of Pharmacy, Azam Campus, Camp Pune-411001, Maharashtra, India.. *Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

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ABSTRACT:
In the present study controlled porosity osmotic pump system (CPOP) has been developed in the presence of different channeling agents in the coating. Ranitidine hydrochloride was chosen as a model drug due to its short half life. The effect of osmogen (sodium chloride) concentrations on the in-vitro release of drug was examined. Cellulose Acetate (CA) was used as a semi permeable membrane. It was found that the rate of drug release increased with change in osmogen concentration due to increased water uptake and hence increased driving force for drug release. The presence of pore forming agents rendered the desired zero order drug release for the period of 10-12 h. The optimized formulations were stable for three months when subjected to stability studies as per ICH guidelines.


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Cite this article:
Jagtap P.C., Awargaonkar A.V., Kuchekar S.B., Bhise K.S.. Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablet of Ranitidine Hydrochloride. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1205-1208.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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