Author(s): Jagtap P.C., Awargaonkar A.V., Kuchekar S.B., Bhise K.S.

Email(s): ksbhise@rediffmail.com

DOI: Not Available

Address: Jagtap P.C., Awargaonkar A.V., Kuchekar S.B. and Bhise K.S.*. Department of Pharmaceutics, MCE Society’s Allana College of Pharmacy, Azam Campus, Camp Pune-411001, Maharashtra, India.. *Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
In the present study controlled porosity osmotic pump system (CPOP) has been developed in the presence of different channeling agents in the coating. Ranitidine hydrochloride was chosen as a model drug due to its short half life. The effect of osmogen (sodium chloride) concentrations on the in-vitro release of drug was examined. Cellulose Acetate (CA) was used as a semi permeable membrane. It was found that the rate of drug release increased with change in osmogen concentration due to increased water uptake and hence increased driving force for drug release. The presence of pore forming agents rendered the desired zero order drug release for the period of 10-12 h. The optimized formulations were stable for three months when subjected to stability studies as per ICH guidelines.


Cite this article:
Jagtap P.C., Awargaonkar A.V., Kuchekar S.B., Bhise K.S.. Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablet of Ranitidine Hydrochloride. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1205-1208.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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