Author(s): M.R. Santhosh Kumar, K.P. Channa Basavaraj, C. Jose Gnana Babu, T. Tamizh Mani

Email(s): Santhosh36524@gmail.com

DOI: Not Available

Address: M.R. Santhosh Kumar*, K.P. Channa Basavaraj, C. Jose Gnana Babu and T. Tamizh Mani
Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya District, Karnataka, India – 571422.
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
A simple, specific, accurate, precise and sensitive Reverse Phase High Performance Liquid Chromatographic method has been developed for the quantitation of Nebivolol in both pure and pharmaceutical dosage forms. A Phenomenex Gemini C-18, 5 µm column having 250 x 4.6 mm internal diameter in isocratic mode with mobile phase containing Acetonitrile : 50mM Ammonium acetate buffer (60 : 40 v/v) and adjust the pH to 3.5 by using glacial acetic acid. The flow rate was 1.0 ml / min and the effluents were monitored at 282 nm. The retention time was 3.783 min. The linearity was in the range of 20-100 µg / ml. This method was validated for linearity, precision, limit of detection, limit of quantitation, accuracy, ruggedness and robustness. Statistical analysis proves that the method is reproducible and selective for the estimation of the said drug.


Cite this article:
M.R. Santhosh Kumar, K.P. Channa Basavaraj, C. Jose Gnana Babu, T. Tamizh Mani. Validated RP- HPLC Method for the Quantitation of Nebivolol in Bulk and Pharmaceutical Dosage Forms. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1167-1169.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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