Yogesh Jadhav, Rajeev Varma, Vrushali Patil, A. S. Bobade, S. V. Athlekar, Abhay Chowdhary
Yogesh Jadhav, Rajeev Varma, Vrushali Patil, A. S. Bobade*, S. V. Athlekar and Abhay Chowdhary
Dept. of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012
Volume - 3,
Issue - 4,
Year - 2010
The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K2CO3 followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS2 and KOH gave potassium salt of thiosemicarbazide which on reaction with excess of hydrazine hydrate in ethanolic medium form 3-(3-pyridoxymethyl)-4-amino-5-mercapto-1,2,4-triazole (II). Compound (II) when condensed with various substituted benzaldehydes gives 3–(3–Pyridoxymethylene)–4–(N–substituted benzylidinylamino)–5–mercapto–1,2,4–triazole derivatives. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).
Cite this article:
Yogesh Jadhav, Rajeev Varma, Vrushali Patil, A. S. Bobade, S. V. Athlekar, Abhay Chowdhary. Synthesis and Study of Some 1, 2, 4-Triazole derivatives. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1144-1147.