Author(s): V. B. Warade, V.N. Deshmukh, S. B. Deshmukh, S. S. Jaiswal, D. M. Sakarkar

Email(s): vikasbwarade@gmail.com

DOI: Not Available

Address: V. B. Warade*, V.N. Deshmukh, S. B. Deshmukh, S. S. Jaiswal and D. M. Sakarkar
Sudhakarrao Naik Institute of Pharmacy, Nagpur Road, Pusad, Dist. Yavatmal - 445 204 (M.S).
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
The recent pharmaceutical application multiparticulate dosage form are gaining much favour over single unit dosage form because of their potential benefit like predictable gastric empting , no risk of dose dumping, flexible release pattern and increase bioavaibility with less inter and intra subject variability. Captopril and Hydrochlorthizide have synergistic antihypertensive action act by inhibiting ACE, block the active reabsorption of sodium (Na+) and chloride (Cl-) with water in the distal tubule respectively. The controlled release multiparticulate drug delivery system was developed by using hydrophilic gums as release modifier polymers. The optimal therapeutic effect of the dosage form was developed using Captopril (t1/2- 1.9 hours) and Hydrochlorothide (t1/2- 6 to 15 hours). In the first step the influence of the combination of Xanthum gum, Karaya gum and Gaur gum on swelling and viscosity were investigated. The combination of Captopril and gum blend in ratio 1:1.5 and Hydrochlorthizide and gum in 1:0.5 ratios are optimized. In general, the release parameters shows that, two major factors control drug release from swelling controlled matrix systems, (i) the rate of aqueous medium infiltration into the matrix, followed by a relaxation process and (ii) the rate of matrix erosion. The controlled release and immediate release preparation are found by their dissolution profile.


Cite this article:
V. B. Warade, V.N. Deshmukh, S. B. Deshmukh, S. S. Jaiswal, D. M. Sakarkar. Formulation and Evaluation of Swellable Controlled Release Multiparticulate Drug Delivery System Using Drug Combination. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1140-1143.


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): P. Geetha, M. Kousalya, S. Geetha Lakshmi, R. Gopi.

DOI: 10.5958/0974-360X.2016.00046.9         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags