Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Analgesic Activity of 2-Hetero Substituted -4-Quinazolinones

Author(s): V. Niraimathi, C. Vamsadhara

Email(s): vnm_anr@yahoo.co.in

DOI: Not Available

Address: V. Niraimathi* and C. Vamsadhara
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

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ABSTRACT:
Analgesic activity of newly synthesized series of 2-heterosubstituted-4-quinazolones (NN, NP, NC, NNB, NPB, NCB) were studied in mice. The analgesic activity was carried out at healthy male Swiss albino mice by writhing method and tail immersion method. Aspirin (150mg/kg p.o) and pentazocin (10mg/kg i.p) were used as positive controls for writhing and tail immersion method respectively. The synthetic compounds were administered orally in the dose of 30mg/kg, 90mg/kg as 1% CMC suspension. Results indicate that statistically significant reduction was obtained at 30mg dose level for compounds NP, NPB and NC by writhing Method. Their p value less than 0.05.


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Cite this article:
V. Niraimathi, C. Vamsadhara. Analgesic Activity of 2-Hetero Substituted -4-Quinazolinones. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1093-1095.


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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