Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation

Author(s): Karunakar Hegde, Cijo Issac, Arun B. Joshi

Email(s): khegde_sh2003@yahoo.co.in

DOI: Not Available

Address: Karunakar Hegde1*, Cijo Issac1 and Arun B. Joshi2
1Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Post-Parangepete, Mangalore- 574143, Karnataka, India.
2Department of Pharmacognosy, Goa College of Pharmacy, Panaji- 403 001, Goa, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

 View HTML        View PDF

ABSTRACT:
In this study, response of ethanolic extract of the roots of C. carandas (ERCC) on membrane lipid peroxidation and antioxidant activity was evaluated by using series of in vitro models of chemical and rat liver homogenate. The ethanolic extract exhibited its radical scavenging effect in concentration dependent manner on 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS), 1,1-diphenyl, 2-picryl hydrazyl (DPPH), super oxide, nitric oxide, erythrocyte haemolysis and the IC50 values found to be 324.93, 185.08, 117.66, 242.69 and 70.82 µg/ml respectively. The extract was also evaluated for its inhibitory response on membrane lipid peroxidation by thiobarbituric acid reactive substances (TBARS) using young and aged rat liver homogenate. The extract was also effective in preventing membrane lipid peroxidation induced by FeSO4/ascorbate in concentration dependent manner. The free radical protective activity may be attributed to its total antioxidant capacity and the presence of total polyphenolic contents. The results obtained in the present study indicate that the ethanolic extract of the roots of C. carandas can be a potential source of natural antioxidant and justify the therapeutic applications of the plant in the indigenous system of medicine.


Keywords:

Cite this article:
Karunakar Hegde, Cijo Issac, Arun B. Joshi. Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1072-1076.

Cite(Electronic):
Karunakar Hegde, Cijo Issac, Arun B. Joshi. Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1072-1076.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-4-125


Recomonded Articles:

Indian Medicinal Plants Used for Treatment of Rheumatoid Arthritis

Author(s): Shyama S. Kumar, Divya Bhosle, Akshay Janghel, Shraddha Deo, Parijeeta Raut, Chetan Verma, Mukta Agrawal, Nisha Amit, Mukesh Sharma, Tapan Giri, D. K. Tripathi1, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2015.00099.2         Access: Open Access Read More

Anti-Cancer Activity of Aloe Vera Ethanolic Leaves Extract against In vitro Cancer Cells

Author(s): Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad

DOI: 10.5958/0974-360X.2019.00360.3         Access: Open Access Read More

Free Radical Scavenging Activity and Total Antioxidant Capacity of Tin Chlorophyllin from Morinda citrifolia L.

Author(s): Pavithra. S, N. Banu

DOI: 10.5958/0974-360X.2017.00091.9         Access: Open Access Read More

Effect of Hesperidin for its Anti-Proliferative Activity on Liver Cancer and Cardio Vascular Diseases.

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

A Review on Antioxidant activity of Psidium guajava

Author(s): R. Manikandan, A. Vijaya Anand

DOI: 10.5958/0974-360X.2015.00056.6         Access: Open Access Read More

Protective effect of Tinospora cordifolia linn., on Paracetamol and Alcohol Induced Hepatotoxicity in Albino Rats.

Author(s): Venkatalakshmi P., Ragadevi M.

DOI: Not Available         Access: Open Access Read More

Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague –Dawley Rat Model

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Determination of Antioxidant Capacity, Flavonoids and Total Phenolic Content of Extracts from Atractylis flava Desf

Author(s): Mohamed Akram Melakhessou, Naima Benkiki, Salah Eddine Marref

DOI: 10.5958/0974-360X.2018.00952.6         Access: Open Access Read More

Histopathologic Changes in Liver Tissue from Cadmium Intoxicated Mice and Treated with Curcumin during Pregnancy

Author(s): Widjiati1, Dewita, Viski F Hendrawan, Kusuma E Purwantari, Syuhuud A Wajdi, Ahmad B Zulfarniasyah, Ainun S Putri, Mitha A Rahmawati, Maulana F Al-Ilmi

DOI: 10.5958/0974-360X.2018.00160.9         Access: Open Access Read More

Evaluation of Antioxidant Potential of Ethanolic Extract of Centella asiatica L

Author(s): Didi Chinnu Raju, T Diana Victoria, Nancy Biji, Gandra Nikitha

DOI: 10.5958/0974-360X.2015.00234.6         Access: Open Access Read More

Antioxidant Activity of Tubers of Arisaema Leschenaultii Blume

Author(s): Gunde MC, Suruse PB, Amnerkar ND, Lohe RW, Godbole MD, Kale MK, Pathak AK

DOI:         Access: Open Access Read More

Endophytic Fungi with Antioxidant Activity- A Review

Author(s): Shylaja Gunasekaran , Shoba Sundaramoorthy , Uma Anitha, Mythili Sathiavelu, Sathiavelu Arunachalam

DOI: 10.5958/0974-360X.2015.00116.X         Access: Open Access Read More

Evaluation of antioxidant and wound healing activity of the leaves of Bridelia airyshawii spreng

Author(s): Yogesh M. Bagad, Mayur R. Bhurat, Anil U. Tatiya, Sanjay J. Surana, Shashikant D. Barhate

DOI: Not Available         Access: Open Access Read More

Role of free radicals in ocular diseases: An overview

Author(s): Preeti K. Suresh, Abhishek K. Sah, Sanjay J. Daharwal

DOI: Not Available         Access: Open Access Read More

Oleic Acid Induced Acute Lung Injury/Acute Respiratory Distress Syndrome Animal Model

Author(s): Tejashree N. Hagawane, Aashish M. Mahuvakar, Rajiv V. Gaikwad, Nilima A. Kshirsagar

DOI: Not Available         Access: Open Access Read More

Investigation of Carvedilol as an Antidenaturing and Anticataract Agent

Author(s): Nimbalkar V.V., Pansare P.M., Nawale D.S., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00085.2         Access: Open Access Read More

Organoselenium as a Cancer Chemopreventive Agent against Carcinogenesis.

Author(s): D Saha, D Mridha, S Mondal, M Jana, S Kayal

DOI: Not Available         Access: Open Access Read More

Screening of Phytochemicals and Comparative Antioxidant activity of Leaf and Fruit of MalaysianMengkudu Using Aqueous and Organic Solvent Extracts.

Author(s): U.S MahadevaRao, Khamsah Suryati Mohd, Siti Zulaikha Bt Abd Halim, Masitah Bt Khamis

DOI: Not Available         Access: Open Access Read More

An Overview of Treatment Challenges and the role of Herbal Antioxidants in Diabetes Mellitus

Author(s): Krishna Ravi, Rosmi Jose, Sumitha SK, Teena Johny, Krishnaveni K, Shanmuga Sundaram R, Sambath Kumar R

DOI: 10.5958/0974-360X.2017.00490.5         Access: Open Access Read More

Antioxidant and Hepatoprotective Activity of Root extract of Baliospermum montanum (Willd) Muell Arg

Author(s): Ahirwar B, Ahirwar D

DOI: 10.5958/0974-360X.2019.00452.9         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Antidiabetes effect of Noni Fruit (Morinda citrifolia L.) on mice with Oral Glucose Tolerance Method and Streptozotocin Induction Method
In-silico Molecular Docking of Coumarin and Naphthalene Derivatives from Pyrenacantha volubilis with the Pathological Mediators of Rheumatoid Arthritis
Cytotoxic and Antimicrobial Activities of Ethyl Acetate Extract from Fungus Trichoderma reesei strain JCM 2267, Aspergillus flavus strain MC- 10-L, Penicillium sp, and Aspergillus fumigatus Associated with Marine Sponge Stylissa flabelliformis
Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique
Formulation and Evaluation of Atorvastatin Solid Dispersions using Entada scandens seed starch as Superdisintegrant
Effect of Orally-administration Niclosamide on serum level of VCAM-1 and E-selectin in Collagen induced arthritis: Experimental study
Chemical Datasets, Antioxidant, Free Radicals Scavenger activities estimate in Aqueous Garlic (Allium sativum) extract
Neuroprotective Activity of the Methanolic Extract of Indigofera aspalathoides against Scopalamine induced Alzheimer
Development of the method for determining Methandienone in Toxicology and doping-analysis
Development and Validation of Head-space Gas Chromatographic Method in Tandem with Flame ionized detection for the determination of Residual solvents in Simeprevir API Synthesis
Effects of Piper betle Leaf Extract on Biofilm and Rhamnolipid Formation of Pseudomonas aeruginosa
A Demographic Study of male infertility and Analysis of semen parameters
Assessment of Calendula officinal growing in Iraq
Piper longum (Linn.) restores ovarian function in Letrozole induced PCOS in Rats: Comparison with Metformin and Clomiphene citrate
Hypocholesterolemic Operating Parameters of Novel Probiotics In vitro
Floating Microsphere of Curcumin as Targeted Gastro-retentive Drug Delivery System
Anti-Urolithiatic Activity of the Ethanolic Extract of Cassia auriculata against Ethylene Glycol Induced Urolithiasis in Experimental Rats
Analgesic and Antipyretic Activities of Ethanolic Extract of Sappan wood (Caesalpinia sappan L.) Leaves
In vitro Anti-oxidant and Anti-inflammatory Activity of the Aqueous and Ethanol Leaf Extracts of Clerodendrum phlomidis Linn. F.
Antimicrobial Efficacy of a Novel Root Canal Irrigant Made from Coconut and Bromelain Extract against Biofilm Forming Pathogens– An In vitro Evaluation

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 7221
Yesterday: 17806
Total: 10610060