Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation

Author(s): Karunakar Hegde, Cijo Issac, Arun B. Joshi

Email(s): khegde_sh2003@yahoo.co.in

DOI: Not Available

Address: Karunakar Hegde1*, Cijo Issac1 and Arun B. Joshi2
1Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Post-Parangepete, Mangalore- 574143, Karnataka, India.
2Department of Pharmacognosy, Goa College of Pharmacy, Panaji- 403 001, Goa, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

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ABSTRACT:
In this study, response of ethanolic extract of the roots of C. carandas (ERCC) on membrane lipid peroxidation and antioxidant activity was evaluated by using series of in vitro models of chemical and rat liver homogenate. The ethanolic extract exhibited its radical scavenging effect in concentration dependent manner on 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS), 1,1-diphenyl, 2-picryl hydrazyl (DPPH), super oxide, nitric oxide, erythrocyte haemolysis and the IC50 values found to be 324.93, 185.08, 117.66, 242.69 and 70.82 µg/ml respectively. The extract was also evaluated for its inhibitory response on membrane lipid peroxidation by thiobarbituric acid reactive substances (TBARS) using young and aged rat liver homogenate. The extract was also effective in preventing membrane lipid peroxidation induced by FeSO4/ascorbate in concentration dependent manner. The free radical protective activity may be attributed to its total antioxidant capacity and the presence of total polyphenolic contents. The results obtained in the present study indicate that the ethanolic extract of the roots of C. carandas can be a potential source of natural antioxidant and justify the therapeutic applications of the plant in the indigenous system of medicine.


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Cite this article:
Karunakar Hegde, Cijo Issac, Arun B. Joshi. Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1072-1076.

Cite(Electronic):
Karunakar Hegde, Cijo Issac, Arun B. Joshi. Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1072-1076.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-4-125


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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